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Radiología intervencionista oncológica experimental y clínica

Líneas de investigación

1. Desarrollo de nanopartículas magnéticas biocompatibles.
2. Estudio "in vivo" de los efectos biológicos provocados por campos electromagnéticos inducidos por generadores externos.
3. Hipertermia antitumoral inducida por nanopartículas magnéticas sometidas a generadores externos de radiofrecuencia.
4. Estudio del efecto antitumoral combinado de la isquemia tisular, la quimioterapia y la hipertermia: desarrollo de micropartículas embolizantes precargadas de quimioterápico y recubiertas de nanopartículas magnéticas con capacidad hipertérmica.
5. Desarrollo de protocolos combinados de ablación térmica, quimioembolización intrarterial y quimioterapia sistémica en el tratamiento del cáncer de colon en estadio avanzado, y en otras estirpes neoplásicas.

Foto grupo

Coordinador/a del grupo



Miembros del grupo

  Javier Alonso Valdesueiro
 
  Idoia Castellanos Rubio
 
  Igone Corta Gómez
 
  Gorka Del Cura Allende
 
 
  José Luis Del Cura Rodríguez
 
 
  Néstor Etxebarria Loizate
 
  Itziar Galarreta Rodríguez
 
  Jose Ángel García Martínez
 
  Ignacio García-Alonso Montoya
 
  Borja Herrero De La Parte
 
  María Teresa Insausti Peña
 
  Mireia Irazola Duñabeitia
 
  Borja Peña Baranda
 
 
  Fernando Plazaola Muguruza
 
  Alberto Sáiz López
 
 
  Rosa María Zabala Landa
 
 
  Beñat Zaldibar Aranburu
 

Publicaciones del grupo

Unzueta Larrinaga P, Barrena Barbadillo R, Ibarra Lecue I, Horrillo I, Villate A, Recio M, et al. Isolation and Differentiation of Neurons and Glial Cells from Olfactory Epithelium in Living Subjects. Mol Neurobiol. 2023; 60(8): 4472-4487. DOI:10.1007/s12035-023-03363-2.

Garcia Alonso I, Velasco Oraa X, Cearra I, Iturrizaga Correcher S, Mar Medina C, Alonso Varona A, et al. Prophylactic Treatment of Intestinal Ischemia-Reperfusion Injury Reduces Mucosal Damage and Improves Intestinal Absorption. Journal of Inflammation Research. 2023; 16: 4141-4152. DOI:10.2147/JIR.S426396.

Galarreta Rodriguez I, Marcano L, Castellanos Rubio I, de Muro IG, Garcia I, Olivi L, et al. Towards the design of contrast-enhanced agents: systematic Ga3+ doping on magnetite nanoparticles. Dalton Trans. 2022; 51(6): 2517-2530. DOI:10.1039/d1dt03029a.

de Santa Maria JGS, de la Parte BH, Gutierrez Sanchez G, Montesinos IR, Correcher SI, Medina CM, et al. Folinic Acid Potentiates the Liver Regeneration Process after Selective Portal Vein Ligation in Rats. Cancers (Basel). 2022; 14(2). DOI:10.3390/cancers14020371.

Echevarria Uraga JJ, Del Cura Allende G, Armendariz Tellitu K, Berastegi Santamaria C, Egurrola Izquierdo M, Anton Ladislao A. Complications and diagnostic accuracy of CT-guided 18G tru-cut versus end-cut percutaneous core needle biopsy of solitary solid lung nodules. Diagn Interv Radiol. 2022; 28(1): 58-64. DOI:10.5152/DIR.2021.20462.

Domingo Echaburu S, Irazola M, Prieto A, Rocano B, De Torre Querejazu AL, Quintana A, et al. Drugs used during the COVID-19 first wave in Vitoria-Gasteiz (Spain) and their presence in the environment. Sci Total Environ. 2022; 820: 153122-153122. DOI:10.1016/j.scitotenv.2022.153122.

Exposito Rodriguez A, Corta Gomez I, Dominguez Ayala M, Garcia Carrillo M, Gonzalez Garcia AI, Gutierrez Rodriguez MT, et al. Sentinel lymph node biopsy in papillary thyroid cancer: Accuracy and application in clinical practice. Cir Esp (Engl Ed). 2022; 100(7): 416-421. DOI:10.1016/j.cireng.2022.04.022.

Herrero de la Parte B, Rodrigo I, Gutierrez Basoa J, Iturrizaga Correcher S, Mar Medina C, Echevarria Uraga JJ, et al. Proposal of New Safety Limits for In Vivo Experiments of Magnetic Hyperthermia Antitumor Therapy. Cancers (Basel). 2022; 14(13). DOI:10.3390/cancers14133084.

Guillermo Bonifacich F, Agustin Lambri O, Raul Mocellini R, Daniel Lambri F, Ignacio Perez Landazabal J, Recarte V, et al. Elastic and Plastic Strains Misfits During the Reverse Martensitic Transformation. Metall Mater Trans A-Phys Metall Mater Sci. 2022; 53(2): 706-722. DOI:10.1007/s11661-021-06558-1.

Rincon Iglesias M, Rodrigo I, Berganza LB, Abu Serea ES, Plazaola F, Lanceros Mendez S, et al. Core-Shell Fe3O4@Au Nanorod-Loaded Gels for Tunable and Anisotropic Magneto- and Photothermia. ACS Appl Mater Interfaces. 2022; 14(5): 7130-7140. DOI:10.1021/acsami.1c20990.

Unzueta I, Gunnlaugsson HP, Molholt TE, Masenda H, Gerami AM, Krastev P, et al. Compositional Dependence of Epitaxial L1(0)-Mn x Ga Magnetic Properties as Probed by Mn-57/Fe and In-119/Sn Emission Mossbauer Spectroscopy. Phys Status Solidi B-Basic Solid State Phys. 2022. DOI:10.1002/pssb.202200121.

Castellanos Rubio I, Baron A, Luis Lizarraga O, Rodrigo I, de Muro IG, Orue I, et al. Efficient Magneto-Luminescent Nanosystems based on Rhodamine-Loaded Magnetite Nanoparticles with Optimized Heating Power and Ideal Thermosensitive Fluorescence. ACS Appl Mater Interfaces. 2022; 14(44): 50033-50044. DOI:10.1021/acsami.2c14016.

Vadillo V, Insausti M, Gutierrez J. Fe xCo1-x alloy nanoparticles: Synthesis, structure, magnetic characterization and magnetorheological application. J Magn Magn Mater. 2022; 563. DOI:10.1016/j.jmmm.2022.169975.

Buron M, Palomares T, Garrido Pascual P, Herrero de la Parte B, Garcia Alonso I, Alonso Varona A. Conditioned Medium from H2O2-Preconditioned Human Adipose-Derived Stem Cells Ameliorates UVB-Induced Damage to Human Dermal Fibroblasts. Antioxidants. 2022; 11(10). DOI:10.3390/antiox11102011.

Herrero de la Parte B, Roa Esparza J, Cearra I, Ruiz Montesinos I, Alonso Alconada D, Alonso Varona A, et al. The Prevention of Ischemia-Reperfusion Injury in Elderly Rats after Lower Limb Tourniquet Use. Antioxidants. 2022; 11(10). DOI:10.3390/antiox11101936.

Nader K, Castellanos Rubio I, Orue I, Iglesias Rojas D, Baron A, Gil de Muro I, et al. Getting insight into how iron(III) oleate precursors affect the features of magnetite nanoparticles. J Solid State Chem. 2022; 316. DOI:10.1016/j.jssc.2022.123619.

Herrero de la Parte B, Gonzalez Arribas M, Diaz Sanz I, Palomares T, Garcia Alonso I. Partial hepatectomy enhances the growth of CC531 rat colorectal cancer cells both in vitro and in vivo. Sci Rep. 2021; 11(1): 5356-5356. DOI:10.1038/s41598-021-85082-z.

Del Cura JL, Del Cura G, Zabala R, Korta I. Contrast-enhanced ultrasonography to guide diagnostic and therapeutic interventional procedures. Radiologia. 2021. DOI:10.1016/j.rx.2021.02.005.

San Cristobal Epalza J, Palomares T, Garcia Alonso I, Herrero de la Parte B. Histological Assessment of Rat Retinas with Ischemia-Reperfusion Injury. Eur Surg Res. 2021; 62(3): 1-7. DOI:10.1159/000515832.

Exposito Rodriguez A, Corta Gomez I, Dominguez Ayala M, Garcia Carrillo M, Gonzalez Garcia AI, Gutierrez Rodriguez MT et al. Sentinel lymph node biopsy in papillary thyroid cancer: Accuracy and application in clinical practice. Cir Esp (Engl Ed). 2021. DOI:10.1016/j.ciresp.2021.04.010.

Esparza JR, Casado MR, Guezuraga IC, Iturrizaga S, Medina CM, Garcia Alonso I et al. PROFILATIC TREATMENT WITH FOLIC ACID FOR LOWER LIMB ISCHAEMIA-REPERFUSION INJURY IN AGED RATS. Br J Surg. 2021; 108: 9-9. DOI:10.1093/bjs/znab160.032.

Capitan MO, Rose S, Sukia IN, de la Parte BH, Montesinos IR, Garcia Alonso I. ENHANCERS OF LIVER REGENERATION IN ONCOLOGICAL SURGERY. Br J Surg. 2021; 108. DOI:10.1093/bjs/znab160.010.

Casado MR, Esparza JR, Iturrizaga S, Medina CM, Garcia Alonso I, de la Parte BH. CURCUMINE REDUCES THE GROWTH OF COLORECTAL LIVER IMPLANTS IN RATS. Br J Surg. 2021; 108

Velasco X, de la Parte BH, Palomares T, Garcia Alonso I. CURCUMIN PREVENTING INTESTINAL ISCHEMIA-REPERFUSION INJURY. Br J Surg. 2021; 108. DOI:10.1093/bjs/znab160.009.

Castellanos Rubio I, Arriortua O, Marcano L, Rodrigo I, Iglesias Rojas D, Baron A et al. Shaping Up Zn-Doped Magnetite Nanoparticles from Mono- and Bimetallic Oleates: The Impact of Zn Content, Fe Vacancies, and Morphology on Magnetic Hyperthermia Performance. Chem Mat. 2021; 33(9): 3139-3154. DOI:10.1021/acs.chemmater.0c04794.

Gutierrez Sanchez G, Garcia Alonso I, Gutierrez Saenz de Santa Maria J, Alonso Varona A, Herrero de la Parte B. Antioxidant-Based Therapy Reduces Early-Stage Intestinal Ischemia-Reperfusion Injury in Rats. Antioxidants (Basel). 2021; 10(6). DOI:10.3390/antiox10060853.

Cearra I, Herrero de la Parte B, Moreno Franco DI, Garcia Alonso I. A reproducible method for biochemical, histological and functional assessment of the effects of ischaemia-reperfusion syndrome in the lower limbs. Sci Rep. 2021; 11(1): 19325-19325. DOI:10.1038/s41598-021-98887-9.

Herrero de la Parte B, Santaolalla Sanchez M, Javier Santaolalla Sanchez F, Garcia Alonso I, Santaolalla F, Sanchez del Rey A. Implementation of a Surgery Congress for Medical Students to Learn Transversal Competences. A Case of Student-Led Teaching Activity. Educ Sci. 2021; 11(9). DOI:10.3390/educsci11090536.

Angel Ulibarrena M, Sainz de Vicuna L, Garcia Alonso I, Lledo P, Gutierrez M, Ulibarrena Garcia A et al. Evolution of Culture on Patient Safety in the Clinical Setting of a Spanish Mutual Insurance Company: Observational Study between 2009 and 2017 Based on AHRQ Survey. Int J Environ Res Public Health. 2021; 18(18). DOI:10.3390/ijerph18189437.

Herrero de la Parte B, Rodeno Casado M, Iturrizaga Correcher S, Mar Medina C, Garcia Alonso I. Curcumin Reduces Colorectal Cancer Cell Proliferation and Migration and Slows In Vivo Growth of Liver Metastases in Rats. Biomedicines. 2021; 9(9). DOI:10.3390/biomedicines9091183.

Palomares T, Arteagoitia I, García de la Fuente AM, Herrero de la Parte B, Bircu D, Ruiz de Azúa S et al. Desarrollo de un plan integral para la adquisición de la competencia de comunicación en el grado en Odontología de la Universidad del País Vasco: un reto institucional. Fem: Revista De La Fundación Educación Médica. 2021; 24(1): 42-47

Cearra I, de la Parte BH, Montesinos IR, Alonso Varona A, Moreno Franco DI, Garcia Alonso I. Effects of Folinic Acid Administration on Lower Limb Ischemia/Reperfusion Injury in Rats. Antioxidants (Basel). 2021; 10(12). DOI:10.3390/antiox10121887.

Gutierrez Basoa J, Alvarez Mora I, Irazola M, Perez Munoz J, Iturrizaga S, Medina CM, et al. RESETTING BREZOVICH-LIMIT BASED ON BIOCHEMICAL AND METABOLOMIC PARAMETERS. Br J Surg. 2020; 107: 13-13

Maria JGSD, Sanchez GG, Garcia Alonso I, Iturrizaga S, Medina CM, de la Parte BH. INFLUENCE OF FOLIC ACID ON LIVER HYPERTROPHY AFTER SELECTIVE PORTAL LIGATURE IN LABORATORY RATS. Br J Surg. 2020; 107: 13-13

Urbano J, Echevarria Uraga JJ, Ciampi Dopazo JJ, Sanchez Corral JA, Alonso JC, Anton Ladislao A, et al. Multicentre prospective study of drug-eluting bead chemoembolisation safety using tightly calibrated small microspheres in non-resectable hepatocellular carcinoma. Eur J Radiol. 2020; 126: 108966-108966. DOI:10.1016/j.ejrad.2020.108966.

Aburto M, Perez Izquierdo J, Agirre U, Barredo I, Echevarria Uraga JJ, Armendariz K, et al. Complications and hospital admission in the following 90 days after lung cryobiopsy performed in interstitial lung disease. Respir Med. 2020; 165: 105934-105934. DOI:10.1016/j.rmed.2020.105934.

Herrero de la Parte B, Garcia Alonso I, Mar Medina C, Iturrizaga S, Saiz Lopez A, Hernandez Farto L, et al. ULTRASOUND TUMOR SIZE ASSESSMENT, HISTOLOGY AND SERUM ENZYME ANALYSIS IN A RAT MODEL OF COLORECTAL LIVER CANCER. Ultrasound Med Biol. 2020; 46(6): 1504-1512. DOI:10.1016/j.ultrasmedbio.2020.02.007.

Castellanos Rubio I, Rodrigo I, Olazagoitia Garmendia A, Arriortua O, Gil de Muro I, Garitaonandia JS, et al. Highly Reproducible Hyperthermia Response in Water, Agar and Cellular Environment by Discretely PEGylated Magnetite Nanoparticles. ACS Appl Mater Interfaces. 2020; 12(25): 27917-27929. DOI:10.1021/acsami.0c03222.

Berastegi Santamaria C, Echevarria Uraga JJ, Garcia Garai N, Jimenez Zapater C, Cura Allende GD. Ureteroarterial fistula treated by endovascular stent placement. Radiology Case Reports. 2020; 15(9): 1714-1717. DOI:10.1016/j.radcr.2020.05.044.

Pereira PL, Iezzi R, Manfredi R, Carchesio F, Bansaghi Z, Brountzos E, et al. The CIREL Cohort: A Prospective Controlled Registry Studying the Real-Life Use of Irinotecan-Loaded Chemoembolisation in Colorectal Cancer Liver Metastases: Interim Analysis. Cardiovasc Interv Radiol. 2020; 44(1): 50-62. DOI:10.1007/s00270-020-02646-8.

Herrero de la Parte B, Irazola Dunabeitia M, Carrero JA, Etxebarria Loizate N, Garcia Alonso I, Echevarria Uraga JJ. Intra-Arterial Infusion of Magnetic Nanoparticle-Based Theragnostic Agent to Treat Colorectal Cancer Liver Implants in Rats. Eur Surg Res. 2020; 61(4-5): 136-142. DOI:10.1159/000512458.

Paja M, Del Cura JL, Zabala R, Korta I, Ugalde A, Lopez JI. Core-needle biopsy in thyroid nodules: performance, accuracy, and complications. Eur Radiol. 2019; 29(9): 4889-4896. DOI:10.1007/s00330-019-06038-6.

Otero Garcia Ramos B, Gonzalez Arribas M, Garcia Alonso I, Herrero de la Parte B. DEVELOPMENT OF A TECHNIQUE FOR CUSTOMIZED CULTURES FROM HUMAN INFILTRATING DUCTAL BREAST CARCINOMA. Br J Surg. 2019; 106(2): 7-7

Herrero de la Parte B, Perez Munoz J, Gutierrez Basoa J, Rodrigo Arrizabalaga I, Garcia JA, Plazaola F, et al. EXPERIMENTAL DETERMINATION OF TOLERANCE LIMITS TO MAGNETIC FIELDS ON MAGNETIC ANTITUMORAL HYPERTHERMIA. Br J Surg. 2019; 106(2): 10-10

Garcia Vazquez M, Herrero de la Parte B, Garcia Alonso I, Morales M. Analysis of Biological Properties of Human Adult Mesenchymal Stem Cells and Their Effect on Mouse Hind Limb Ischemia. J Vasc Res. 2019; 56(2): 77-91. DOI:10.1159/000498919.

Katsumiti A, Nicolussi G, Bilbao D, Prieto A, Etxebarria N, Cajaraville MP. In vitro toxicity testing in hemocytes of the marine mussel Mytilus galloprovincialis (L) to uncover mechanisms of action of the water accommodated fraction (WAF) of a naphthenic North Sea crude oil without and with dispersant. Sci Total Environ. 2019; 670: 1084-1094. DOI:10.1016/j.scitotenv.2019.03.187.

Gonzalez Arribas M, Garcia Alonso I, Herrero De La Parte B. EFFECT OF PARTIAL HEPATECTOMY ON THE DEVELOPMENT OF LIVER METASTASES IN AN EXPERIMENTAL MURINE MODEL. Br J Surg. 2019; 106(2): 5-5

Gutierrez Saenz J, Gutierrez Sanchez G, Garcia Alonso I, Herrero de la Parte B. DEVELOPMENT OF AN EXPERIMENTAL MODEL TO STUDY PORTAL LIGATURE IN LABORATORY RATS. Br J Surg. 2019; 106(2): 6-6

Gutierrez Sanchez G, Gutierrez Saenz J, Garcia Alonso I, Herrero de la Parte B. NON OCCLUSIVE MESENTERIC ISCHAEMIA IN AN EXPERIMENTAL MURINE MODEL. SET-UP OF A SURGICAL PROCEDURE. Br J Surg. 2019; 106(2): 8-8

Del Cura JL, Coronado G, Zabala R, Korta I, López I. Accuracy and effectiveness of ultrasound-guided core-needle biopsy in the diagnosis of focal lesions in the salivary glands. Eur Radiol. 2018; 28(7): 2934-2941. DOI:10.1007/s00330-017-5295-9.

Unzueta I, Lopez Garcia J, Sanchez Alarcos V, Recarte V, Perez Landazabal JI, Rodriguez Velamazan JA, et al. Sn-119 Mossbauer spectroscopy in the study of metamagnetic shape memory alloys. Hyperfine Interact. 2018; 239. DOI:10.1007/s10751-018-1509-z.

Ziarrusta H, Mijangos L, Irazola M, Prieto A, Etxebarria N, Anakabe E, et al. Ciprofloxacin by-products in seawater environment in the presence and absence of gilt-head bream. Chemosphere. 2018; 197: 560-568. DOI:10.1016/j.chemosphere.2018.01.069.

Rodriguez Abreu D, Campillo J, Grau F, Carcereny E, Bernabe R, Garcia Y, et al. NIVEX TRIAL (GECP 1605): Nivolumab in the Real World: Spanish Expanded Access Program Experience in Pretreated Advanced NSCLC Patients. J Thorac Oncol. 2018; 13(10): 827-827. DOI:10.1016/j.jtho.2018.08.1467.

Castellanos Rubio I, Munshi R, Qin Y, Eason DB, Orue I, Insausti M, et al. Multilayered inorganic-organic microdisks as ideal carriers for high magnetothermal actuation: assembling ferrimagnetic nanoparticles devoid of dipolar interactions. Nanoscale. 2018; 10(46): 21879-21892. DOI:10.1039/c8nr03869d.

Ziarrusta H, Mijangos L, Picart Armada S, Irazola M, Perera Lluna A, Usobiaga A, et al. Non-targeted metabolomics reveals alterations in liver and plasma of gilt-head bream exposed to oxybenzone. Chemosphere. 2018; 211: 624-631. DOI:10.1016/j.chemosphere.2018.08.013.

Spirou SV, Costa Lima SA, Bouziotis P, Vranjes Djuric S, Efthimiadou EK, Laurenzana A, et al. Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy. Nanomaterials. 2018; 8(5). DOI:10.3390/nano8050306.

Pajuelo Corral O, Rodriguez Dieguez A, Garcia JA, San Sebastian E, Seco JM, Cepeda J. Chiral coordination polymers based on d(10) metals and 2-aminonicotinate with blue fluorescent/green phosphorescent anisotropic emissions. Dalton Trans. 2018; 47(26): 8746-8754. DOI:10.1039/c8dt01159a.

Arriortua OK, Insausti M, Lezama L, Gil de Muro I, Garaio E, de la Fuente JM, et al. RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia. Colloids Surf B Biointerfaces. 2018; 165: 315-324. DOI:10.1016/j.colsurfb.2018.02.031.

Lopez Garcia J, Unzueta I, Sanchez Alarcos V, Recarte V, Perez Landazabal JI, Rodriguez Velamazan JA, et al. Correlation between defects and magneto-structural properties in Ni-Mn-Sn metamagnetic shape memory alloys. Intermetallics. 2018; 94: 133-137. DOI:10.1016/j.intermet.2017.12.028.

Galarreta I, Insausti M, Gil de Muro I, Ruiz de Larramendi I, Lezama L. Exploring Reaction Conditions to Improve the Magnetic Response of Cobalt-Doped Ferrite Nanoparticles. Nanomaterials. 2018; 8(2). DOI:10.3390/nano8020063.

Nemati Z, Alonso J, Rodrigo I, Das R, Garaio E, Angel Garcia J, et al. Improving the Heating Efficiency of Iron Oxide Nanoparticles by Tuning Their Shape and Size. J Phys Chem C Nanomater Interfaces. 2018; 122(4): 2367-2381. DOI:10.1021/acs.jpcc.7b10528.

Agustin Lambri O, Victor Giordano ED, Guillermo Bonifacich F, Jimenez Ruiz M, Antonella Lambri M, Ariel Sanchez F, et al. Changes in the crystalline degree in neutron irradiated EPDM viewed through infrared spectroscopy and inelastic neutron scattering. Materia. 2018; 23(2). DOI:10.1590/S1517-707620180002.0415.

Guillermo Bonifacich F, Agustin Lambri O, Ignacio Perez Landazabal J, Recarte V, Gargicevich D, Irene Zelada G, et al. Study of the martensitic transition in Ni-Mn-Sn-Ti ferromagnetic shape memory alloys. Materia. 2018; 23(2). DOI:10.1590/S1517-707620180002.0379.

Tesis del grupo

Autor/a: Roque Oca Pernas. Título: "Utilidad de las secuencias de difusión de resonancia magnética en el diagnóstico inicial de las tumoraciones de partes blandas ". Directores/as: Dr. Ignacio García-Alonso Montoya, Dr. Teodoro Palomares Casado.

Autor/a: Oscar Atillo Taibo . Título: "Relación entre el diámetro arterial vertebral igual o menor de 3 mm y la reducción de su flujo sanguíneo durante la manipulación osteopática cervical que incluye el parámetro de inclinación". Directores/as: Dr. Pedro Rolando Grandes Moreno , Dr. José Luis del Cura Rodríguez.

Autor/a: Borja Herrero de la Parte. Título: ""Hipertermia magnética antitumoral mediada por nanopartículas magnéticas RGD en el tratamiento de metátasis hepáticas en un modelo experimental murino"". Directores/as: Dr. Ignacio García- Alonso Montoya, Dr. José Javier Echevarria Uraga.

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