BEGIKER
BEGIKER
Actividades del grupo
Uveítis. Es la línea de investigación principal del grupo. En este campo estamos interesados en la patogenia del edema macular. En concreto estamos valorando el papel de la somatostatina como factor anti permeabilidad capilar y por tanto como potencial arma terapéutica frente a esta complicación.
También estamos interesados en el papel de la genética en la patogenia de las uveítis intermedia y posteriores inmunes. En este sentido vamos a iniciar un estudio multicéntrico junto con el Hospital Clínic de Barcelona, La Fe de Valencia, el hospital Clínico San Carlos de Madrid, el Hospital de Granada, el Hospital de Valdecilla y el CESIC en el que vamos a estudiar posibles genes candidatos implicados en estas enfermedades.
Unos de nuestros objetivos es obtener un producto celular capaz de regenerar la superficie ocular en casos de insuficiencia limbar total. El daño severo del limbo esclero-corneal es una patología ocular que afecta a las células madre del limbo o a su nicho, pudiendo provocar ceguera. Esta enfermedad es muy incapacitante y afecta a una población muy diversa, puesto que la causa puede ser tanto de origen inmunológico como ser consecuencia de traumatismos o quemaduras químicas en sujetos sanos. Además, implica importantes costes sanitarios a largo plazo.
La insuficiencia limbar precisa de una reparación de la población de células madre del limbo para obtener una recuperación duradera de la superficie ocular. Para ello, es necesario realizar un trasplante de las células madre al ojo afectado, ya sean provenientes de un individuo donante (cadáver o pariente vivo) (trasplante alogénico) ya sean del propio individuo (del ojo contralateral) (trasplante autólogo).
El cultivo de células madre del propio ojo del paciente permitiría la repoblación celular conservando la capacidad de auto-replicación celular. Asimismo, se evitaría el uso de medicaciones con alto grado de morbilidad necesarias para los trasplantes alogénicos, que en la mayoría de los casos fracasan, así como el peligro severo de descompensación del ojo inicialmente sano en casos de trasplante autólogo a partir del ojo contralateral.
Por otra parte, estudiamos el efecto regenerador y cicatrizante de distintos hemoderivados ricos en factores de crecimiento plaquetarios sobre la superficie corneal en casos de defecto epitelial.
La salud de la superficie ocular depende de la integridad del epitelio corneal. En casos de defecto epitelial corneal persistente, que no responden a los tratamientos estándar, se han descrito diferentes métodos para mejorar el tropismo de la superficie ocular. Entre ellos, y desde hace una década aproximadamente, se ha venido estudiando el efecto de preparados autólogos derivados de la sangre con un alto contenido en plaquetas, o en factores de crecimiento liberados por las plaquetas. Sin embargo, no existe consenso en el método de preparación de los mismos.
Los procesos de cicatrización son muy complejos y requieren la activación de múltiples vías de señalización implicadas en mecanismos tales como la homeostasis, inflamación, proliferación celular y remodelación tisular. Debido a la necesaria participación e interacción de distintos factores de crecimiento, estos hemoderivados ricos en factores plaquetarios ofrecen importantes expectativas para la regeneración corneal.
En los trastornos de aprendizaje, en concreto, en los trastornos de la lectura, siempre ha existido mucha controversia sobre su etiología, lo cual ha llevado a que exista un gran mercado de pacientes "desorientados". En ese aspecto, se ha dado un paso de gigante con las nuevas técnicas de imagen. Con nuestro estudio pretendemos demostrar que la dislexia tiene un origen neurológico y que en absoluto es un problema perceptivo. Para ello, realizamos resonancia magnética funcional en niños con dislexia y en niños con trastornos en la motilidad ocular, además de en un grupo control, para conocer los grupos neuronales que activan durante la lectura los diferentes grupos de niños. El objetivo final de nuestra investigación es saber si podemos utilizar la RMf como método diagnóstico de la dislexia.
Existe un grupo importante de niños con alergias oculares subclínicas, que son mal diagnosticados como tics y tratados como tal. Para corregir esa situación pretendemos desarrollar un kit de diagnóstico de conjuntivitis alérgica a través de la lagrima de los pacientes, para ello primero debemos de conocer los mediadores moleculares en lagrima de la alergia ocular infantil. Por ello, realizamos un análisis de los posibles marcadores de alergia en niños con una conjuntivitis alérgica conocida y en niños control. Con posterioridad, una vez conocidos éstos, desarrollaremos un kit que sea capaz de detectarlos.
Tenemos una tercera actividad que consiste en verificar si somos capaces de forma prenatal de diagnosticar patologías oculares severas e intentar integrarlas en un marcador diagnóstico global de malformaciones. Para ello, se toman muestras de líquido amniótico en madres de niños que pueden tener patologías oculares hereditarias y valorar si detectamos la anomalía genética ya conocida en dicho líquido.
Coordinador/a del grupo
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Alejandro Fonollosa Calduch
Coordinador de grupo
alejandro.fonollosacalduch@osakidetza.eus
CV resumen
Miembros del grupo
Publicaciones del grupo
Pato Cour E, Martin Martinez MA, Borrego Sanz L, Martinez Costa L, Esteban Ortega M, Sanchez Costa JT, et al. Validation of UVEDAI: An Index for Evaluating the Level of Inflammatory Activity in Uveitis. OPHTHALMOL THER. 2023; 12(2): 1045-1055. DOI:10.1007/s40123-023-00654-8.
Lucas Jiménez O, Ibarretxe Bilbao N, Diez I, Pena J, Tijero B, Galdós M, et al. Brain Degeneration in Synucleinopathies Based on Analysis of Cognition and Other Nonmotor Features: A Multimodal Imaging Study. Biomedicines. 2023; 11(2). DOI:10.3390/biomedicines11020573.
Pato Cour E, Martin Martinez MA, Borrego Sanz L, Martinez Costa L, Esteban Ortega M, Sanchez Costa JT, et al. Validation of UVEDAI: An Index for Evaluating the Level of Inflammatory Activity in Uveitis (Jan, 10.1007/s40123-023-00654-8, 2023). OPHTHALMOL THER. 2023; 12(2): 1057-1058. DOI:10.1007/s40123-023-00681-5.
Banuelos AO, Carro AS, Lera RF, Ecenarro JE. Sterile corneal necrosis after bowman layer transplantation. Eur J Ophthalmol. 2023; 33(4): 1558-1566. DOI:10.1177/11206721231165438.
Banuelos AO, Carro AS, Lera RF, Eguen CS, Victoriano NA, Ecenarro JE. Candida Colonization on the Surface of Contact Lenses in Long-Term Wearers and Boston Type 1 Keratoprosthesis Patients Presenting as White Mulberry-Shaped Deposits. Eye Contact Lens-Sci Clin Pra. 2023; 49(5): 188-192. DOI:10.1097/ICL.0000000000000984.
Chauhan K, Fonollosa A, Giralt L, Artaraz J, Randerson EL, Goldstein DA, et al. Demystifying Ocular Syphilis - A Major Review. Ocul Immunol Inflamm. 2023; 31(7): 1425-1439. DOI:10.1080/09273948.2023.2217246.
Vitale A, Della Casa F, Guerriero S, Ragab G, Mauro A, Caggiano V, et al. Efficacy and Safety of Adalimumab in Pediatric Non-infectious Non-anterior Uveitis: Real-life Experience From the International AIDA Network Uveitis Registry. OPHTHALMOL THER. 2023; 12(4): 1957-1971. DOI:10.1007/s40123-023-00712-1.
Gaggiano C, Del Bianco A, Sota J, Gentileschi S, Ruscitti P, Giacomelli R, et al. A patient-driven registry on Behcet's disease: the AIDA for patients pilot project. Front Med. 2023; 10. DOI:10.3389/fmed.2023.1188021.
Penas C, Arroyo Berdugo Y, Apraiz A, Rasero J, Munoa Hoyos I, Andollo N, et al. Pirin is a prognostic marker of human melanoma that dampens the proliferation of malignant cells by downregulating JARID1B/KDM5B expression. Sci Rep. 2023; 13(1). DOI:10.1038/s41598-023-36684-2.
Martin Saborido C, Zarranz Ventura J, Escobar Barranco JJ, Garay Aramburu G, Garcia Layana A, Donate Lopez J, et al. Cost-utility model of new intravitreous units vs. current patient journey model in Spain. Arch Soc Esp Oftalmol (Engl Ed). 2023. DOI:10.1016/j.oftale.2023.08.009.
Fanlo P, Roman MLS, Fonollosa A, Ilarramendi J, Heras H, Grayson P. Episcleritis and periorbital edema secondary to VEXAS syndrome. Arch Soc Esp Oftalmol (Engl Ed). 2023; 98(10): 607-610. DOI:10.1016/j.oftale.2023.07.004.
Garay Aramburu G, Rodriguez Feijoo D, Aldazabal Echeveste M, Del Barrio Z, Eiras Fernandez A, Pinero DP, et al. Predictors of stoppage and recurrence of choroidal neovascularization with a Treat- Extend-Stop protocol: 4-year follow-up. J Fr Ophtalmol. 2023. DOI:10.1016/j.jfo.2023.02.021.
Sanchez Quiros J, Giralt L, Fonollosa A, Robles I, Carreno E. Diagnostic and Management Strategies of Tubulointerstitial Nephritis and Uveitis Syndrome (TINU): Current Perspectives. Clin Ophthalmol. 2023; 17: 2625-2630. DOI:10.2147/OPTH.S404644.
Hernanz I, Moll Udina A, Garcia Tirado A, Garcia Fernandez M, Gutierrez Ezquerro R, Garcia Arumi C, et al. The retinal bacillary layer detachment: Clinical features and outcomes in posterior uveitis. J Fr Ophtalmol. 2023; 46(8): 916-920. DOI:10.1016/j.jfo.2022.12.031.
Martin Pinardel R, Izquierdo Serra J, De Zanet S, Parrado Carrillo A, Garay Aramburu G, Puzo M, et al. Artificial intelligence-based fluid quantification and associated visual outcomes in a real-world, multicentre neovascular age-related macular degeneration national database. Br J Ophthalmol. 2023. DOI:10.1136/bjo-2022-322297.
Pueyo V, Cedillo Ley M, Fanlo Zarazaga A, Hu L, Pan X, Perez Roche T, et al. Colour perception develops throughout childhood with increased risk of deficiencies in children born prematurely. Acta Paediatr. 2023. DOI:10.1111/apa.16978.
Fonollosa A, Pelegrin L, Garcia Morillo S, Bujan Rivas S, Distefano L, Robles Maruenda A, et al. Ocular involvement in adult and paediatric patients with monogenic autoinflammatory diseases: a Spanish multicentre retrospective study. Clin Exp Rheumatol. 2023; 41(10): 2105-2114. DOI:10.55563/clinexprheumatol/ukegcc.
Orive Banuelos A, Fideliz de la Paz M, Feijoo Lera R, Santamaria Carro A, Martinez Grau A, Andollo Victoriano N, et al. Transmucosal Boston Keratoprosthesis Type II in a Case of Severe Bilateral Chemical Burn. Cornea. 2023. DOI:10.1097/ICO.0000000000003426.
Mansour AM, Lopez Guajardo L, Belotto S, Lima LH, Charbaji AR, Schwartz SG, et al. Recovery course of persistent posterior subretinal fluid after successful repair of rhegmatogenous retinal detachment. Eur J Ophthalmol. 2023. DOI:10.1177/11206721231210693.
Gaggiano C, Gupta V, Agrawal R, De Smet MD, Frediani B, Tosi GM, et al. Knowledge and Current Practices in Monogenic Uveitis: An International Survey by IUSG and AIDA Network. OPHTHALMOL THER. 2023. DOI:10.1007/s40123-023-00839-1.
Zarranz Ventura J, Parrado Carrillo A, Nguyen V, Sararols L, Garay Aramburu G, Puzo M, et al. Creation of a Neovascular Age-related Macular Degeneration National Database using a web-based platform: Fight Retinal Blindness SPAIN. Report 1. Visual outcomes. Clin Exp Ophthalmol. 2022; 50(3): 312-324. DOI:10.1111/ceo.14054.
Acera A, Gomez Esteban JC, Murueta Goyena A, Galdos M, Azkargorta M, Elortza F, et al. Potential Tear Biomarkers for the Diagnosis of Parkinson's Disease-A Pilot Study. Proteomes. 2022; 10(1). DOI:10.3390/proteomes10010004.
Macias Murelaga B, Garay Aramburu G, Bergado Mijangos R, Coello Ojeda D, Ozaeta I, Garcia Gomez PJ, et al. Prediction Error Stabilization and Long-Term Standard Results with a Monofocal Intraocular Lens. Vision (basel, Switzerland). 2022; 6(1). DOI:10.3390/vision6010005.
Ruzafa N, Pereiro X, Vecino E. Immunohistochemical Characterisation of the Whale Retina. Front Neuroanat. 2022; 16. DOI:10.3389/fnana.2022.813369.
Fonollosa A, Hernandez Rodriguez J, Cuadros C, Giralt L, Sacristan C, Artaraz J, et al. CHARACTERIZING COVID-19-RELATED RETINAL VASCULAR OCCLUSIONS A Case Series and Review of the Literature. Retin-J Retin Vitr Dis. 2022; 42(3): 465-475. DOI:10.1097/IAE.0000000000003327.
Giralt L, Perez Fernandez S, Adan A, Figueira L, Fonollosa A, IBERTINU Study GRP. Clinical Features and Outcomes of Tubulointerstitial Nephritis and Uveitis Syndrome in Spain and Portugal: The IBERTINU Project. Ocul Immunol Inflamm. 2022. DOI:10.1080/09273948.2022.2026413.
Agrawal R, Weng RC, Fonollosa A, Giralt L, Artaraz J, Yang PZ, et al. Outcome Measures for Disease Monitoring in Intraocular Inflammatory and Infectious Diseases (OCTOMERIA): Understanding the Choroid in Uveitis with Optical Coherence Tomography (OCT). Ocul Immunol Inflamm. 2022. DOI:10.1080/09273948.2022.2026414.
Rivas AB, Lopez Picado A, Calamia V, Carreno E, Cocho L, Cordero Coma M, et al. Efficacy, safety and cost-effectiveness of methotrexate, adalimumab or their combination in non-infectious non-anterior uveitis: a protocol for a multicentre, randomised, parallel three arms, active-controlled, phase III open label with blinded outcome assessment study. Bmj Open. 2022; 12(3). DOI:10.1136/bmjopen-2021-051378.
Silva LSCD, Finamor LPS, Andrade GC, Lima LH, Zett C, Muccioli C, et al. Vascular retinal findings after COVID-19 vaccination in 11 cases: a coincidence or consequence?. Arquivos Brasileiros De Oftalmologia. 2022; 85(2). DOI:10.5935/0004-2749.20220071.
Valsero Franco S, Fonollosa A. Ischemic Optic Neuropathy After Administration of a SARS-CoV-2 Vaccine: A Report of 2 Cases. Am J Case Rep. 2022; 23. DOI:10.12659/AJCR.935095.
Galletero Pandelo L, Olaso Fernandez H, Sanchez Aparicio JA, Rodriguez Vidal C, Martinez Alday N. Results of large macular hole surgery using different interposition techniques. A report on 9 cases. Arch Soc Esp Oftalmol (Engl Ed). 2022; 97(8): 457-463. DOI:10.1016/j.oftale.2022.03.010.
Pereiro X, Beriain S, Rodriguez L, Roiz Valle D, Ruzafa N, Vecino E. Characteristics of Whale Muller Glia in Primary and Immortalized Cultures. Front Neurosci. 2022; 16. DOI:10.3389/fnins.2022.854278.
Acera A, Abad B, Pereiro X, Rodriguez FD, Ruzafa N, Duran JA, et al. Comparative study of the lipid profile of tears and plasma enriched in growth factors. Exp Eye Res. 2022; 219. DOI:10.1016/j.exer.2022.109061.
Pereiro X, Beriain S, Rodriguez L, Ruzafa N, Roiz Valle D, Freije JMP, et al. Characterization of primary and immortalized whale Muller Glial cells. Acta Ophthalmol. 2022; 100. DOI:10.1111/j.1755-3768.2022.216.
Pereiro X, Ruzafa N, Beriain S, Vecino E. Effect of Sei and Fin whale Muller glia in the survival and neurite growth of RGCs in vitro. Acta Ophthalmol. 2022; 100. DOI:10.1111/j.1755-3768.2022.217.
Ruzafa N, Pereiro X, Vecino E. Morphological characterization of the whale retina. Acta Ophthalmol. 2022; 100. DOI:10.1111/j.1755-3768.2022.218.
Giralt Peret L, Rodriguez Urzay A, Perez Fernandez S, Martinez Alday N, Fonollosa Calduch A. Real-life results in treating neovascular age-related macular degeneration with anti-VEGF therapy. Analysis of 122 patients from a single centre. Arch Soc Esp Oftalmol (Engl Ed). 2022; 97(4): 191-197. DOI:10.1016/j.oftale.2021.02.007.
Hidalgo MR, Ezquerra Inchausti M, Escudero Arraras L, Lara Lopez A, Galdos M, Aldazabal M, et al. Mutation spectrum of inherited retinal dystrophies in a cohort from the Basque Country (Spain). Eur J Hum Genet. 2022; 30(SUPPL 1): 129-129
de la Fuente M, Rodríguez Agirretxe I, Vecino E, Astigarraga E, Acera A, Barreda Gómez G. Elevation of Tear MMP-9 Concentration as a Biomarker of Inflammation in Ocular Pathology by Antibody Microarray Immunodetection Assays. Int J Mol Sci. 2022; 23(10). DOI:10.3390/ijms23105639.
Banuelos AO, Larrea BA, Crnej A, Soto AA, Victoriano NA, Ecenarro JE. Transscleral Cyclophotocoagulation for the Treatment of Uncontrolled Glaucoma in a Boston Keratoprosthesis Type II Patient. Case Rep in Ophthalmology. 2022; 13(1): 158-165. DOI:10.1159/000522440.
Rodriguez Vidal C, Galletero Pandelo L, Artaraz J, Fonollosa A. Bacillary layer detachment in a patient with serpiginoid choroiditis. Indian J Ophthalmol. 2022; 70(7): 2687-2689. DOI:10.4103/ijo.IJO_2174_21.
Valsero Franco S, Bernal Morales C, Santos Zorrozua B, Aranzamendi Zalmumbide M, Artaraz Beobide J, Sainz Maza M, et al. Herpetic anterior uveitis multicentre longitudinal study (The UVHER project). Baseline characteristics. Ocul Immunol Inflamm. 2023; 31(7): 1497-1504. DOI:10.1080/09273948.2022.2103829.
Fonollosa A, Carreno E, Agarwal A. Editorial: Multimodal imaging in uveitis. Front Med (Lausanne). 2022; 9: 1011628-1011628. DOI:10.3389/fmed.2022.1011628.
Romo Valera C, Guerrero P, Arluzea J, Etxebarria J, de la Caba K, Andollo N. BIOLOGICAL ASSESSMENT OF PROTEIN-BASED BIOMATERIALS AS POTENTIAL CANDIDATES FOR CORNEAL BIOENGINEERING. Tissue Eng Part A. 2022; 28: 510-510
Garay Aramburu G, Bergado Mijangos R, Irizar Amilleta R, Saez Espejo B, Serrano Zurbitu L, Arakama Alustiza J, et al. Risk factors for predicted refractive error after cataract surgery in clinical practice. Retrospective observational study. Arch Soc Esp Oftalmol (Engl Ed). 2022; 97(3): 140-148. DOI:10.1016/j.oftale.2022.02.004.
Avendano Monje CL, Cordero Coma M, Mauriz JL, Calleja Antolin S, Fonollosa A, Garrote Llorden A, et al. Anti-retinal Antibodies in Sarcoidosis. Ocul Immunol Inflamm. 2022: 1-7. DOI:10.1080/09273948.2022.2129693.
Santamaria A, Perez S, De Luis B, Orive A, Feijoo R, Etxebarria J. Clinical characteristics and prognostic factors of open globe injuries in a North Spain population: a 10-year review. Eye. 2023; 37(10): 2101-2108. DOI:10.1038/s41433-022-02297-8.
Fonollosa A, Charcan I, Giralt L, Artaraz J, Soto A, Ruiz Arruza I, et al. Hyper-Reflective Outer Nuclear Layer (HONL) in Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia. Ocul Immunol Inflamm. 2022. DOI:10.1080/09273948.2022.2134038.
Romero Bascones D, Ayala U, Alberdi A, Erramuzpe A, Galdos M, Gomez Esteban JC, et al. Spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology. PLoS One. 2022; 17(12): 278925-278925. DOI:10.1371/journal.pone.0278925.
Perez Roche MT, Yam JC, Liu HU, Gutierrez D, Pham C, Balasanyan V, et al. Visual Acuity and Contrast Sensitivity in Preterm and Full-Term Children Using a Novel Digital Test. Children-Basel. 2022; 10(1). DOI:10.3390/children10010087.
Gegundez Fernandez JA, Llovet Osuna F, Fernandez Vigo JI, Mendicute del Barrio J, Pablo Julvez L, Munoz Negrete FJ et al. Recommendations for ophthalmologic practice during the easing of COVID-19 control measures. Acta Ophthalmol. 2021; 99(7): 973-983. DOI:10.1111/aos.14752.
Vegas Revenga N, Martin Varillas JL, Calvo Rio V, Gonzalez Mazon I, Sanchez Bilbao L, Beltran E et al. Intravenous methylprednisolone induces rapid improvement in non-infectious uveitis: a multicentre study of 112 patients. Clin Exp Rheumatol. 2021; 40(1): 142-149. DOI:10.55563/clinexprheumatol/imrgo2.
Ruzafa N, Pereiro X, Fonollosa A, Araiz J, Acera A, Vecino E. The Effect of Plasma Rich in Growth Factors on Microglial Migration, Macroglial Gliosis and Proliferation, and Neuronal Survival. Front Pharmacol. 2021; 12: 606232-606232. DOI:10.3389/fphar.2021.606232.
Romo Valera C, Guerrero P, Arluzea J, Etxebarria J, de la Caba K, Andollo N. Cytocompatibility and Suitability of Protein-Based Biomaterials as Potential Candidates for Corneal Tissue Engineering. Int J Mol Sci. 2021; 22(7). DOI:10.3390/ijms22073648.
Ruzafa N, Pereiro X, Fonollosa A, Araiz J, Acera A, Vecino E. Plasma Rich in Growth Factors (PRGF) Increases the Number of Retinal Muller Glia in Culture but Not the Survival of Retinal Neurons. Front Pharmacol. 2021; 12: 606275-606275. DOI:10.3389/fphar.2021.606275.
Blanco Urrejola M, Gaminde Blasco A, Gamarra M, de la Cruz A, Vecino E, Alberdi E et al. RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons. Cells. 2021; 10(3). DOI:10.3390/cells10030632.
Cuadros Sanchez C, Eguen CS, Gutierrez Ezquerro R, Giralt Peret L, Fonollosa A. Central Retinal Vein Occlusion Presumably Associated with Lupus Anticoagulant Induced by SARSCoV-2. Ocul Immunol Inflamm. 2021. DOI:10.1080/09273948.2021.1933077.
Arriola Villalobos P, Moll Udina A, Carrasco Brea M, Sacristan C, Jose Capella M, Peiteado D et al. Vogt-Koyanagi-Harada disease in Spain. Eur J Ophthalmol. 2021; 32(3): 1547-1554. DOI:10.1177/11206721211033477.
Romero Bascones D, Barrenechea M, Murueta Goyena A, Galdos M, Gomez Esteban JC, Gabilondo I et al. Foveal Pit Morphology Characterization: A Quantitative Analysis of the Key Methodological Steps. Entropy (Basel). 2021; 23(6). DOI:10.3390/e23060699.
Garay Aramburu G, Gomez Moreno A, Urcola A. Short-term effectiveness prognostic factors after dexamethasone intravitreal implant in macular edema due to retinal vein occlusion. Eur J Ophthalmol. 2022; 32(3): 1671-1679. DOI:10.1177/11206721211032520.
Zijlmans BLM, van Zijderveld R, Manzulli M, Garay Aramburu G, Czapski P, Eter N et al. Global multi-site, prospective analysis of cataract surgery outcomes following ICHOM standards: the European CAT-Community. Graefes Arch Clin Exp Ophthalmol. 2021; 259(7): 1897-1905. DOI:10.1007/s00417-021-05181-5.
Guemes Villahoz N, Diaz Valle D, Fonollosa A, Jimenez Santos M, Narvaez Palazon C, Adan A. Spontaneous resolution of inflammatory epiretinal membrane: Case series and review of the literature. Eur J Ophthalmol. 2021. DOI:10.1177/11206721211036291.
Del Amo C, Perez Valle A, Perez Garrastachu M, Jauregui I, Andollo N, Arluzea J et al. Plasma-Based Bioinks for Extrusion Bioprinting of Advanced Dressings. Biomedicines. 2021; 9(8). DOI:10.3390/biomedicines9081023.
Romo Valera C, Perez Garrastachu M, Hernaez Moya R, Rodriguez Astigarraga M, Romano Ruiz P, Etxebarria J et al. Characterisation of corneas following different time and storage methods for their use as a source of stem-like limbal epithelial cells. Exp Eye Res. 2021; 211. DOI:10.1016/j.exer.2021.108720.
del Pino R, Acera M, Murueta Goyena A, Lucas Jimenez O, Ojeda N, Ibarretxe Bilbao N et al. Visual dysfunction is associated with cognitive impairment in Parkinson's disease. Parkinsonism Relat Disord. 2021; 92: 22-25. DOI:10.1016/j.parkreldis.2021.10.005.
Moreno Castro L, Garcia GP, Artaraz J, Fonollosa A. Fluocinolone Implant for Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis Syndrome: A Case Report. Case Rep in Ophthalmology. 2021; 12(3): 824-830. DOI:10.1159/000518011.
de la Fuente M, Lombardero L, Gomez Gonzalez A, Solari C, Angulo Barturen I, Acera A et al. Enzyme Therapy: Current Challenges and Future Perspectives. Int J Mol Sci. 2021; 22(17). DOI:10.3390/ijms22179181.
Lafuente C, Vecino E. Scientific dissemination in a photographic exhibition on the anatomical study eye of the whale's eye adapted for people with visual disabilities. Arte Individuo Soc. 2021; 33(4): 1449-1471. DOI:10.5209/aris.72501.
Gabrielle PH, Nguyen V, Arnold JJ, Bhandari S, Viola F, Tigchelaar Besling O et al. Three-Year Outcomes of Neovascular Age-Related Macular Degeneration in Eyes That Do Not Develop Macular Atrophy or Subretinal Fibrosis. Transl Vis Sci Technol. 2021; 10(13). DOI:10.1167/tvst.10.13.5.
Vegas Revenga N, Martin Varillas JL, Calvo Rio V, Gonzalez Mazon I, Sanchez Bilbao L, Beltran E et al. RAPID IMPROVEMENT IN CYSTOID MACULAR EDEMA WITH HIGH DOSE INTRAVENOUS METHYLPREDNISOLONE IN NON-INFECTIOUS UVEITIS OF DIFFERENT IMMUNE MEDIATED INFLAMMATORY DISEASES. Ann Rheum Dis. 2021; 80: 1225-1226. DOI:10.1136/annrheumdis-2021-eular.3247.
Vegas Revenga N, Martin Varillas JL, Calvo Rio V, Gonzalez Mazon I, Sanchez Bilbao L, Beltran E et al. HIGH DOSE INTRAVENOUS METHYLPREDNISOLONE INDUCES RAPID IMPROVEMENT OF VISUAL ACUITY IN NON-INFECTIOUS UVEITIS OF DIFFERENT IMMUNE MEDIATED INFLAMMATORY DISEASES. Ann Rheum Dis. 2021; 80: 1412-1412. DOI:10.1136/annrheumdis-2021-eular.2159.
Vegas Revenga N, Martin Varillas JL, Calvo Rio V, Gonzalez Mazon I, Sanchez Bilbao L, Catalan EB et al. High Dose Intravenous Methylprednisolone Induces Rapid Improvement of Visual Acuity in Non-Infectious Uveitis of Different Immune Mediated Inflammatory Diseases. Arthritis Rheumatol. 2021; 73: 394-396
Vegas Revenga N, Martin Varillas JL, Calvo Rio V, Gonzalez Mazon I, Sanchez Bilbao L, Catalan EB et al. Rapid Improvement in Cystoid Macular Edema with High Dose Intravenous Methylprednisolone in Non-Infectious Uveitis of Different Immune Mediated Inflammatory Diseases. Arthritis Rheumatol. 2021; 73: 396-398
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Beltran Catalan E, Calvo Rio V, Rodriguez Cundin P, Blanco Alonso R, Sanchez Burson J, Mesquida M, et al. COMPARATIVE STUDY OF INFLIXIMAB VERSUS ADALIMUMAB IN PATIENTS WITH REFRACTORY UVEITIS DUE TO BEHCET'S DISEASE. MULTICENTER STUDY OF 125 CASES. Ann Rheum Dis. 2014; 73(2): 557-557. DOI:10.1136/annrheumdis-2014-eular.4766.
Beltran Catalan E, Calvo Rio V, Blanco Alonso R, Ortego Centeno N, Garcia Serrano JL, Martinez Costa Perez L, et al. HIGH DOSE INTRAVENOUS METHYLPREDNISOLONE INDUCES RAPID IMPROVEMENT IN SEVERE OCULAR INFLAMMATION. MULTICENTER STUDY OF 104 CASES. Ann Rheum Dis. 2014; 73(2): 995-995. DOI:10.1136/annrheumdis-2014-eular.4735.
Cénit MC, Márquez A, Cordero-Coma M, Gorroño-Echebarría MB, Fonollosa A, Adán A, et al. No Evidence of Association between Common Autoimmunity STAT4 and IL23R Risk Polymorphisms and Non-Anterior Uveitis. PLoS One. 2013;8:e72892. FI: 3,730(Q1)
Márquez A, Cénit MC, Cordero-Coma M, Ortego-Centeno N, Adán A, Fonollosa A, et al. Two Functional Variants of IRF5 Influence the Development of Macular Edema in Patients with Non-Anterior Uveitis. PLoS One. 2013;8:e76777. FI: 3,730(Q1)
Loricera J, Calvo-Rio V, Blanco R, Mesquida M, Adan AM, Herreras JM, et al. Biologic Therapy In Refractory Uveitis Of Sarcoidosis. Multicenter Study Of 16 Patients. Arthritis Rheum. 2013;65:859. FI: 7,477(Q1). (Meeting Abstract)
Ortiz-Sanjuan F, Calvo-Rio V, Blanco R, Beltran E, Sanchez-Burson J, Mesquida M, et al. Biologic Therapy In Refractory Uveitis Of Behcet's Syndrome: Switching and Dose Modification. Multicenter Study Of 124 Patients. Arthritis Rheum. 2013;65:1118-9. FI: 7,477(Q1)
Ortiz-Sanjuan F, Calvo-Rio V, Blanco R, Beltran E, Sanchez-Burson J, Mesquida M, et al. Short and Long-Term Biological Therapy In Refractory Uveitis Of Behcet's Syndrome. Multicenter Study Of 124 Patients. Arthritis Rheum. 2013;65:743-4. FI: 7,477(Q1). (Meeting Abstract)
Carmen Cenit M, Marquez A, Cordero-Coma M, Fonollosa A, Adan A, Martinez-Berriotxoa A, et al. Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition. BMC Med Genet. 2013;14:52. FI: 2,536(Q3)
Pinar-Sueiro S, Zorrilla Hurtado JÁ, Veiga-Crespo P, Sharma SC, Vecino E. Neuroprotective effects of topical CB1 agonist WIN 55212-2 on retinal ganglion cells after acute rise in intraocular pressure induced ischemia in rat. Exp Eye Res. 2013;110:55-8. FI: 3,026(Q1)
Cénit MC, Márquez A, Cordero-Coma M, Fonollosa A, Llorenç V, Artaraz J, et al. Lack of association between the protein tyrosine phosphatase non-receptor type 22 R263Q and R620W functional genetic variants and endogenous non-anterior uveitis. Mol Vis. 2013;19:638-43. FI: 1,987(Q2)
Arana B, Fonollosa A, Artaraz J, Martinez-Berriotxoa A, Martinez-Alday N. Macular hole secondary to toxoplasmic retinochoroiditis. Int Ophthalmol. 2013;34:141-3. FI: 0,000(Q0)
García-De-Vicuña C, Díaz-Llopis M, Salom D, Bou R, Díaz-Cascajosa J, Cordero-Coma M, et al. Usefulness of Adalimumab in the Treatment of Refractory Uveitis Associated with Juvenile Idiopathic Arthritis. Mediators Inflamm. 2013;2013:560632 FI: 3,882(Q2)
Garcia-Vazquez MD, Morales MC, Mateos-Mazon JJ, Ayestaran J, Fernandez-Conti P, Gomez-Coloma A, et al. Pathology of donor, harvest site and culture medium could determinate mesenchymal stem cell properties. Hum Gene Ther. 2013;24:101. FI: 4,019(Q1). (Meeting Abstract).
Hernaez-Moya R, Etxebarria J, Freire V, Morales MC, Duran JA, Andollo N. The Rabbit as a modelfor in vivo preclinical experimentation in limbal deficiency: Optimization of primary cultures of rabbit limbal cells. Hum Gene Ther. 2013;24:141. FI: 4,019(Q1). (Meeting Abstract).
Garcia I, Etxebarria J, Merayo-Lloves J, Torras J, Boto-de-los-Bueis A, Diaz-Valle D, et al. Novel Molecular Diagnostic System of Limbal Stem Cell Deficiency Based on MUC5AC Transcript Detection in Corneal Epithelium by PCR-Reverse Dot Blot Invest Ophthalmol. Vis Sci. 2013;54:5643-52. FI: 3,441(Q1)
Soria J, Durán JA, Etxebarria J, Merayo J, González N, Reigada R, et al. Tear proteome and protein network analyses reveal a novel pentamarker panel for tear film characterization in dry eye and meibomian gland dysfunction. J Proteomics. 2013;78:94-112. FI: 4,088(Q1)
Durán de la Colina JA. CongresS.O.S. Arch Soc Esp Oftalmol. 2013;88:1-2. FI: 0,000(Q0)
Barrio-Barrio J, Noval S, Galdós M, Ruiz-Canela M, Bonet E, Capote M, et al. Multicenter Spanish study of spectral-domain optical coherence tomography in normal children. Acta Ophthalmol. 2013;91:56-63. FI: 2,345(Q2)
Tesis del grupo
Autor/a: Jaime Echevarria Ecenarro. Título: "Mecanismos celulares de la regeneración del defecto epitelial corneal tratado con suero derivado de plasma rico en factores de crecimiento (s-PRGF) en solitario y combinado". Directores/as: Dra. Mª Noelia Andollo Victoriano, Dr. Juan A Durán de la Colina.
Autor/a: Vanesa Freire Vallejo. Título: Derivados hemáticos en la regeneración del epitelio corneal: estudio comparativo in vitro e in vivo. Director/a: Dra. Noelia Andollo Victoriano, Dra. Celia Morales González. UPV/EHU
