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Enfermedades infecciosas

Líneas de investigación

Infecciones hospitalarias y asociadas a cuidados sanitarios.
Implantación de PROA hospitalario y coordinación con la atención primaria (Programa de Optimización del uso de Antibióticos)
Complicaciones infecciosas en los receptores de trasplante de órgano sólido
Infecciones intravasculares: endocarditis e infecciones asociadas a implantes cardiovasculares.
Infección osteoarticular y asociada a prótesis osteoarticular. Infección en el pie diabético.
Infecciones en pacientes inmunodeprimidos por enfermedades onco-hematológicas, terapias inmunosupresoras y biológicos.
Infecciones del viajero, tropicales y emergentes. Infección COVID.
Infección por el VIH y otras infecciones de transmisión sexual.

Foto grupo

Actividades del grupo

Las infecciones hospitalarias y las asociadas con los cuidados sanitarios constituyen un problema importante de salud pública, tanto por la morbilidad y mortalidad que causan, como por el coste económico que generan, en especial en pacientes con alta complejidad, como los atendidos en nuestro hospital.

Desde la implantación del PROA en nuestro hospital, realizamos una atención diaria de todos los casos con bacteriemia o funguemia, así como de las infecciones asociadas a catéteres, procedimientos invasivos, diarrea por Clostridioides difficile…etc. Los resultados de este programa se reflejan en la mejoría del uso de antimicrobianos, la evidencia del descenso del uso de antimicrobianos de amplio espectro y de la incidencia contenida de infecciones por microorganismos multirresistentes en nuestra OSI.

En esta línea participamos en numerosos estudios multicéntricos y ensayos clínicos basados en la epidemiología, tratamientos antimicrobianos y pronóstico de las personas infectadas por microorganismos multirresistentes y somos activos en la divulgación de conocimiento tanto en nuestra actividad diaria con otros profesionales como en cursos de formación.

El Hospital Universitario Cruces es centro de referencia de trasplante de órgano sólido de la Comunidad (hepático y renal); muchos pacientes son remitidos a nuestras consultas para su valoración pretrasplante y atendemos las complicaciones infecciosas del período postrasplante.

La Endocarditis Infecciosa continúa siendo un proceso infeccioso con una mortalidad excesiva y con escasa modificación en la última década. Colaboramos muy activamente en el grupo nacional GAMES (Grupo de Apoyo al Manejo de la Endocarditis Infecciosa). En nuestro centro hemos creado un grupo multidisciplinar para la toma de decisiones de forma colegiada con otros especialistas relacionados con el manejo de esta patología. Analizamos los cambios producidos en la última década en la epidemiología de la endocarditis infecciosa, y tenemos especial interés en la precisión diagnóstica y el tratamiento quirúrgico oportuno. Gracias a esta participación hemos logrado visualizar nuestro trabajo diario en múltiples publicaciones nacionales e internacionales.

Las infecciones de prótesis osteoarticulares se asocian como es bien conocido con una importante morbilidad. Lideramos el grupo multidisciplinar de manejo de esta patología compleja e integramos nuestra experiencia a registros nacionales con difusión nacional e internacional.

La unidad de pie diabético de nuestro centro está conformada por numerosos especialistas con los que colaboramos en la atención de las complicaciones infecciosas de estos pacientes, atendidos en una consulta monográfica de nuestro servicio. Este grupo mantiene una actividad formativa y científica que refleja la larga trayectoria en esta patología.

Las infecciones en pacientes inmunodeprimidos por enfermedades onco-hematológicas y otros pacientes que reciben terapias inmunosupresoras y basadas en fármacos biológicos, como es el caso de las enfermedades autoinmunes, son muy prevalentes y pueden ser devastadoras debido al riesgo de adquisición de infecciones causadas por microorganismos oportunistas. Nuestra colaboración en su atención se refleja en numerosas publicaciones de estudios multicéntricos españoles dirigidos a su estudio.

Los pacientes con infecciones del viajero y tropicales reciben atención y seguimiento en una consulta monográfica cuya actividad es registrada en la red nacional REDIVI (Red cooperativa para el estudio de las Infecciones importadas por Viajeros e Inmigrantes) con participación de los especialistas nacionales más relevantes de este campo.

Las infecciones por microorganismos emergentes son hoy en día de inmenso interés por su desconocimiento y riesgo de epidemias o pandemias con rápida extensión geográfica debido a los movimientos migratorios o viajeros. La pandemia por SARS-CoV2 ha sido el mejor ejemplo de ello; así, a comienzos del 2020 nos vimos obligados a una actualización continuada del conocimiento científico generado para ofrecer la mejor asistencia posible a nuestros pacientes, a ofrecer terapia farmacológica de nueva generación participando en ensayos clínicos de interés mundial, así como a difundir las medidas del mejor manejo posible mediante protocolos actualizados para los clínicos del hospital y publicaciones científicas.

La infección por VIH constituye un problema de primera línea para los infectólogos desde sus inicios en la década de 1980-90. Hoy en día seguimos en la atención de personas que viven con VIH mediante una valoración holística en la que, además de los tratamientos retrovirales de eficacia conocida, el paciente es asistido en todos los acontecimientos relacionados con esta infección crónica. Entre estos destacamos la infección por VHC que, con la incorporación de los nuevos fármacos de acción directa, han logrado la curación en los últimos años incluso aquellos pacientes coinfectados con VIH y VHC. No obstante, continúa siendo un área de vigilancia de nuevas infecciones y control de aquellos ya tratados.

Por otro lado, nuestro centro es de referencia en trasplante de órgano sólido (hepático y renal) en personas que viven con VIH y desde sus comienzos, participamos como investigadores en registros nacionales, analizando datos epidemiológicos, complicaciones infecciosas y no infecciosas como el rechazo o fallo del injerto que desarrollan los pacientes.

Las infecciones de transmisión sexual son otra área de interés y asistencia en nuestro servicio dada su prevalencia ascendente, mediante una consulta monográfica donde los pacientes son remitidos desde los servicios de Urgencias u otros especialistas. Se realiza una atención precoz del problema infeccioso, así como educación y tratamiento para la prevención de las mismas en sujetos en riesgo.

Las enfermedades infecciosas afectan a pacientes de toda índole y atención por todo tipo de especialistas médicos. Nuestro grupo fomenta la formación continuada en el área de las enfermedades infecciosas mediante cursos acreditados. El objetivo es ampliar el conocimiento en aquellos profesionales que en su labor diaria requieren un adecuado manejo diagnóstico y terapéutico de las complicaciones infecciosas.

Coordinador/a del grupo



Miembros del grupo

  María José Blanco Vidal
 
 
  Mikel del Álamo Martínez
 
 
  Gorane Euba Ugarte
 
 
  Ane Josune Goikoetxea Aguirre
 
 
  Laura Guio Carrión
 
 
  Marta Ibarrola Hierro
 
 
  Javier Nieto Arana
 
 
  Regino José Rodriguez Álvarez
 
 

Publicaciones del grupo

Sojo Dorado J, Lopez Hernandez I, Rosso Fernandez C, Morales IM, Palacios Baena ZR, Hernandez Torres A, et al. Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections A Randomized Clinical Trial. JAMA Netw Open. 2022; 5(1). DOI:10.1001/jamanetworkopen.2021.37277.

Norman FF, Salvador F, Gullon B, Diaz Menendez M, Perez Ayala A, Rodriguez Guardado A, et al. Frequency and characteristics of HTLV in migrants: Results from the +Redivi collaborative network in Spain. J Travel Med. 2022. DOI:10.1093/jtm/taac019.

Garcia Alvarez L, Garcia C, Munoz P, Farinas Alvarez MC, Cuadra MG, Fernandez Hidalgo N, et al. Bartonella Endocarditis in Spain: Case Reports of 21 Cases. Pathogens. 2022; 11(5). DOI:10.3390/pathogens11050561.

Martinez Perez Crespo PM, Rojas A, Lanz Garcia JF, Retamar Gentil P, Reguera Iglesias JM, Lima Rodriguez O, et al. Pseudomonas aeruginosa Community-Onset Bloodstream Infections: Characterization, Diagnostic Predictors, and Predictive Score Development-Results from the PRO-BAC Cohort. Antibiotics-Basel. 2022; 11(6). DOI:10.3390/antibiotics11060707.

Cerrada Romero C, Berastegui Cabrera J, Camacho Martinez P, Goikoetxea Aguirre J, Perez Palacios P, Santibanez S, et al. Excretion and viability of SARS-CoV-2 in feces and its association with the clinical outcome of COVID-19. Sci Rep. 2022; 12(1). DOI:10.1038/s41598-022-11439-7.

Mussa M, Martinez Perez Crespo PM, Lopez Cortes LE, Retamar Gentil P, Sousa Dominguez A, Goikoetxea Aguirre AJ, et al. Risk Factors and Predictive Score for Bacteremic Biliary Tract Infections Due to Enterococcus faecalis and Enterococcus faecium: a Multicenter Cohort Study from the PROBAC Project. Microbiol Spectr. 2022: 5122-5122. DOI:10.1128/spectrum.00051-22.

Norman FF, Trevino Maruri B, Ruiz Giardin JM, Gullon Pena B, Salvador F, Serre N, et al. Trends in imported malaria during the COVID-19 pandemic, Spain ( plus Redivi Collaborative Network). J Travel Med. 2022; 29(6). DOI:10.1093/jtm/taac083.

Mejia Chew C, Carver PL, Rutjanawech S, Aranha Camargo LF, Fernandes R, Belga S, et al. Risk Factors for Nontuberculous Mycobacteria Infections in Solid Organ Transplant Recipients: A Multinational Case-Control Study. Clin Infect Dis. 2022. DOI:10.1093/cid/ciac608.

Montejano R, de la Calle Prieto F, Velasco M, Guijarro C, Queiruga Parada J, Jimenez Gonzalez M, et al. Tenofovir Disoproxil Fumarate/Emtricitabine and Baricitinib for Patients at High Risk of Severe Coronavirus Disease 2019: The PANCOVID Randomized Clinical Trial. Clin Infect Dis. 2022. DOI:10.1093/cid/ciac628.

Dominguez Cainzos J, Rodrigo Manjon A, Rodriguez Chinesta JM, Apodaka Diez A, Bonmati G, Bereciartua E. Abdominal aortic endograft infection. A decade of experience and literature review. Enferm Infecc Microbiol Clin (Engl Ed). 2022. DOI:10.1016/j.eimce.2022.07.002.

Alvarez Zaballos S, Gonzalez Ramallo V, Quintana E, Munoz P, De la Villa Martinez S, Farinas MC, et al. Multivalvular Endocarditis: A Rare Condition with Poor Prognosis. J Clin Med. 2022; 11(16). DOI:10.3390/jcm11164736.

van Melle JP, Roos Hesselink JW, Bansal M, Kamp O, Meshaal M, Pudich J, et al. Infective endocarditis in adult patients with congenital heart disease. Int J Cardiol. 2022. DOI:10.1016/j.ijcard.2022.10.136.

Fernandez Ruiz M, Bodro M, Gutierrez Martin I, Rodriguez Alvarez R, Ruiz Ruigomez M, Sabe N, et al. Isavuconazole for the Treatment of Invasive Mold Disease in Solid Organ Transplant Recipients: A Multicenter Study on Efficacy and Safety in Real-life Clinical Practice. Transplantation. 2022. DOI:10.1097/TP.0000000000004312.

Rombauts A, Infante C, de Lagos MAM, Alba J, Valiente A, Donado Mazarron C, et al. Impact of SARS-CoV-2 RNAemia and other risk factors on long-COVID: A prospective observational multicentre cohort study. J Infect. 2022. DOI:10.1016/j.jinf.2022.11.009.

Pericas JM, Ambrosioni J, Munoz P, de Alarcon A, Kestler M, Mari Hualde A et al. Prevalence of Colorectal Neoplasms Among Patients With Enterococcus faecalis Endocarditis in the GAMES Cohort (2008-2017). Mayo Clin Proc. 2021; 96(1): 132-146. DOI:10.1016/j.mayocp.2020.06.056.

Zenarruzabeitia O, Astarloa Pando G, Terren I, Orrantia A, Perez Garay R, Seijas Betolaza I et al. T Cell Activation, Highly Armed Cytotoxic Cells and a Shift in Monocytes CD300 Receptors Expression Is Characteristic of Patients With Severe COVID-19. Front Immunol. 2021; 12. DOI:10.3389/fimmu.2021.655934.

Duena L, Varona J, Bereciartua E, Lopez L. In the shadow of the pandemic. Enferm Infecc Microbiol Clin (Engl Ed). 2021. DOI:10.1016/j.eimc.2021.03.006.

Rodriguez Pardo D, del Toro MD, Guio Carrion L, Escudero Sanchez R, Fernandez Sampedro M, Garcia Viejo MA et al. Role of asymptomatic bacteriuria on early periprosthetic joint infection after hip hemiarthroplasty. BARIFER randomized clinical trial. Eur J Clin Microbiol Infect Dis. 2021; 40(11): 2411-2419. DOI:10.1007/s10096-021-04241-2.

Gioia F, Filigheddu MT, Corbella L, Fernandez Ruiz M, Lopez Medrano F, Perez Ayala A et al. Invasive aspergillosis in solid organ transplantation: Diagnostic challenges and differences in outcome in a Spanish national cohort (Diaspersot Study). Mycoses. 2021; 64(11): 1334-1345. DOI:10.1111/myc.13298.

Delgado E, Fernandez Garcia A, Perez Losada M, Moreno Lorenzo M, Fernandez Miranda I, Benito S et al. Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America. Sci Rep. 2021; 11(1): 11442-11442. DOI:10.1038/s41598-021-90023-x.

Lucas A, Chamorro Tojeiro S, Llenas Garcia J, Salvador F, Zubero Z, Molina I et al. Imported leptospirosis in travellers and migrants in Spain: a study of the +REDIVI collaborative network. J Travel Med. 2021; 28(6). DOI:10.1093/jtm/taab095.

Pericas JM, Hernandez Meneses M, Munoz P, Alvarez Uria A, Pinilla Llorente B, de Alarcon A et al. Outcomes and Risk Factors of Septic Shock in Patients With Infective Endocarditis: A Prospective Cohort Study. Open Forum Infect Dis. 2021; 8(6): 119-119. DOI:10.1093/ofid/ofab119.

Varela Barca L, Vidal Bonnet L, Farinas MC, Munoz P, Valerio Minero M, de Alarcon A et al. Analysis of sex differences in the clinical presentation, management and prognosis of infective endocarditis in Spain. Heart. 2021; 107(21): 1717-1724. DOI:10.1136/heartjnl-2021-319254.

Gutierrez Villanueva A, Munoz P, Delgado Montero A, Olmedo Samperio M, de Alarcon A, Gutierrez Carretero E et al. Mural Endocarditis: The GAMES Registry Series and Review of the Literature. Infect Dis Ther. 2021; 10(4): 2749-2764. DOI:10.1007/s40121-021-00490-y.

Delgado E, Fernandez Garcia A, Perez Losada M, Moreno Lorenzo M, Fernandez Miranda I, Benito S et al. Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America (vol 11, 11442, 2021). Sci Rep. 2021; 11(1). DOI:10.1038/s41598-021-95679-z.

Dominguez Cainzos J, Rodrigo Manjon A, Rodriguez Chinesta JM, Apodaka Diez A, Bonmati G, Bereciartua E. Abdominal aortic endograft infection. A decade of experience and literature review. Enferm Infecc Microbiol Clin. 2021. DOI:10.1016/j.eimc.2021.06.018.

Mancheno Losa M, Lora Tamayo J, Fernandez Sampedro M, Rodriguez Pardo D, Munoz Mahamud E, Soldevila L et al. arthroplasty revision: A large multicenter cohort. J Infect. 2021; 83(5): 542-549. DOI:10.1016/j.jinf.2021.09.001.

Pando GA, Zenarruzabeitia O, Terren I, Orrantia A, Garay RP, Betolaza IS et al. T cell activation, highly armed cytotoxic cells and a shift in monocytes CD300 receptors expression in severe COVID-19. Eur J Immunol. 2021; 51: 267-267

Cardozo C, Cuervo G, Salavert M, Merino P, Gioia F, Fernández Ruiz M, et al. An evidence-based bundle improves the quality of care and outcomes of patients with candidaemia. J Antimicrob Chemother. 2020; 75(3): 730-737. DOI:10.1093/jac/dkz491.

Varela Barca L, Fernández Felix BM, Navas Elorza E, Mestres CA, Muñoz P, Cuerpo Caballero G, et al. Prognostic assessment of valvular surgery in active infective endocarditis: multicentric nationwide validation of a new score developed from a meta-analysis. Eur J Cardio-Thorac Surg. 2020; 57(4): 724-731. DOI:10.1093/ejcts/ezz328.

López Medrano F, Silva JT, Fernández Ruiz M, Vidal E, Origüen J, Calvo Cano A, et al. Oral fosfomycin for the treatment of lower urinary tract infections among kidney transplant recipients-Results of a Spanish multicenter cohort. Am J Transplant. 2020; 20(2): 451-462. DOI:10.1111/ajt.15614.

Gudiol C, Albasanz Puig A, Laporte Amargós J, Pallarès N, Mussetti A, Ruiz Camps I, et al. A clinical predictive model of multidrug resistance in neutropenic cancer patients with bloodstream infection due to Pseudomonas aeruginosa (IRONIC study). Antimicrob Agents Chemother. 2020; 64(4). DOI:10.1128/AAC.02494-19.

Len O, Los Arcos I, Aguado JM, Blanes M, Bodro M, Carratalà J, et al. Selection criteria of solid organ donors in relation to infectious diseases: A Spanish consensus. Transplant Rev. 2020; 34(2): 100528-100528. DOI:10.1016/j.trre.2020.100528.

Erdozain J, Pijoan J, Villar I, Nieto J, Ruiz Arruza I, Ruiz Irastorza G, et al. Ankle-brachial index and arterial vascular events in systemic lupus erythematosus patients: a 5-year prospective cohort. Clin Exp Rheumatol. 2020

San Juan R, Fernández Ruiz M, Ruiz Ruigómez M, López Medrano F, Ruiz Merlo T, Andrés A, et al. A new clinical and immuno-virological score for predicting the risk of late severe infection in solid organ transplant recipients: the CLIV Score. J Infect Dis. 2020; 222(3): 479-487. DOI:10.1093/infdis/jiaa090.

Bassetti M, Vena A, Meroi M, Cardozo C, Cuervo G, Giacobbe DR, et al. Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts. Crit Care. 2020; 24(1): 117-117. DOI:10.1186/s13054-020-2793-y.

Ramos Vivas J, Chapartegui González I, Fernández Martínez M, González Rico C, Fortún J, Escudero R, et al. Author Correction: Biofilm formation by multidrug resistant Enterobacteriaceae strains isolated from solid organ transplant recipients. Sci Rep. 2020; 10(1): 7452-7452. DOI:10.1038/s41598-020-60496-3.

Erdozain J, Pijoan J, Villar I, Nieto J, Ruiz Arruza I, Ruiz Irastorza G, et al. Ankle-brachial index and arterial vascular events in systemic lupus erythematosus patients: a 5-year prospective cohort. Clin Exp Rheumatol. 2020

Monte Armenteros J, Bereciartua Bastarrica E, Jimenez Maestre U, Guio Carrion L. [Bilateral pneumonia in a patient with Cushing's syndrome]. Rev Esp Quimioter. 2020; 33(4): 278-280. DOI:10.37201/req/001.2020.

Pujol M, Miro J, Shaw E, Aguado J, San Juan R, Puig Asensio M, et al. Daptomycin plus Fosfomycin versus Daptomycin Alone for Methicillin-Resistant Staphylococcus aureus Bacteremia and Endocarditis. A Randomized Clinical Trial. Clin Infect Dis. 2020; 72(9): 1517-1525. DOI:10.1093/cid/ciaa1081.

Ramos Martinez A, Pericas JM, Fernandez Cruz A, Munoz P, Valerio M, Kestler M, et al. Four weeks versus six weeks of ampicillin plus ceftriaxone in Enterococcus faecalis native valve endocarditis: A prospective cohort study. PLoS One. 2020; 15(8): 237011-237011. DOI:10.1371/journal.pone.0237011.

Paez Vega A, Cantisan S, Aguera ML, Suner M, Facundo C, Yuste JR, et al. Pretransplant CMV-specific T-cell immunity but not dose of antithymocyte globulin is associated with recovery of specific immunity after kidney transplantation. J Infect Dis. 2020; 223(7): 1205-1213. DOI:10.1093/infdis/jiaa503.

Prieto M, Gastaca M, Ruiz P, Ventoso A, Palomares I, Rodriguez Alvarez RJ, et al. A case of COVID-19 immediately after liver transplantation: Not only bad news. Ann Hepatobiliary Pancreat Surg. 2020; 24(3): 314-318. DOI:10.14701/ahbps.2020.24.3.314.

Merchante N, Rodriguez Fernandez M, Figueruela B, Rodriguez Arrondo F, Revollo B, Ibarra S, et al. Impact of HIV on the survival of hepatocellular carcinoma in hepatitis C virus-infected patients. Aids. 2020; 34(10): 1497-1507. DOI:10.1097/QAD.0000000000002578.

Ruiz Irastorza G, Pijoan J, Bereciartua E, Dunder S, Dominguez J, Garcia Escudero P, et al. Second week methyl-prednisolone pulses improve prognosis in patients with severe coronavirus disease 2019 pneumonia: An observational comparative study using routine care data. PLoS One. 2020; 15(9): 239401-239401. DOI:10.1371/journal.pone.0239401.

Goikoetxea Agirre AJ, Ibarrola Hierro M, Nieto Arana J, Martinez de Lagos MA. Vesicular (varicella-like) eruptions. Enferm Infecc Microbiol Clin. 2020. DOI:10.1016/j.eimc.2020.07.006.

Ramos Vivas J, Chapartegui Gonzalez I, Fernandez Martinez M, Gonzalez Rico C, Barrett J, Fortun J, et al. Adherence to Human Colon Cells by Multidrug Resistant Enterobacterales Strains Isolated From Solid Organ Transplant Recipients With a Focus on Citrobacter freundii. Front Cell Infect Microbiol. 2020; 10: 447-447. DOI:10.3389/fcimb.2020.00447.

Escuredo IM, Elorduy EV, Carrion LG, Segura JE, Arcarazo PI, Gutierrez JGJ. Mycobacterium abscessus Infection after Breast Lipotransfer: A Report of 2 Cases. PRS-GLOB OPEN. 2020; 8(8). DOI:10.1097/GOX.0000000000003063.

Pierrotti LC, Perez Nadales E, Fernandez Ruiz M, Gutierrez B, Hock Tan B, Carratala J, et al. Efficacy of beta-lactam/beta-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients (INCREMENT-SOT Project). Transpl Infect Dis. 2020; 23(3): 13520-13520. DOI:10.1111/tid.13520.

Farinas MC, Gonzalez Rico C, Fernandez Martinez M, Fortun J, Escudero R, Moreno A, et al. Oral decontamination with colistin plus neomycin in solid organ transplant recipients colonized by multidrug-resistant Enterobacterales: a multicenter, randomized, controlled, open-label, parallel-group clinical trial. Clin Microbiol Infect. 2020; 27(6): 856-863. DOI:10.1016/j.cmi.2020.12.016.

Salvador F, Trevino B, Chamorro Tojeiro S, Pou D, Herrero Martinez JM, Rodriguez Guardado A, et al. Epidemiological and clinical profile of immunosuppressed patients with imported strongyloidiasis: a substudy from a larger cohort of the plus REDIVI Spanish Collaborative Network. Pathog Glob Health. 2020; 115(2): 121-124. DOI:10.1080/20477724.2020.1857491.

de las Revillas FA, Sousa D, Ardanuy C, Garcia Vidal C, Montejo M, Rodriguez Alvarez R, et al. Healthcare-associated pneumonia: a prospective study in Spain. Rev Esp Quimioter. 2020; 33(5): 358-368. DOI:10.37201/req/067.2020.

Albasanz Puig A, Gudiol C, Parody R, Tebe C, Akova M, Araos R, et al. Impact of antibiotic resistance on outcomes of neutropenic cancer patients with Pseudomonas aeruginosa bacteraemia (IRONIC study): study protocol of a retrospective multicentre international study. Bmj Open. 2019; 9(5). DOI:10.1136/bmjopen-2018-025744.

Henriquez Camacho C, Serre M, Norman F, Sanchez Montalva A, Torrus D, Josune Goikoetxea A, et al. Clinicoepidemiological characteristics of viral hepatitis in migrants and travellers of the plus Redivi network. Travel Med Infect Dis. 2019; 29: 51-57. DOI:10.1016/j.tmaid.2019.02.001.

Benito N, Mur I, Ribera A, Soriano A, Rodriguez Pardo D, Sorli L, et al. The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms. J Clin Med. 2019; 8(5). DOI:10.3390/jcm8050673.

Salvador F, Trevino B, Chamorro Tojeiro S, Sanchez Montalva A, Maria Herrero Martinez J, Rodriguez Guardado A, et al. Imported strongyloidiasis: Data from 1245 cases registered in the plus REDIVI Spanish Collaborative Network (2009-2017). Plos Neglect Trop Dis. 2019; 13(5). DOI:10.1371/journal.pntd.0007399.

Morata L, Cobo J, Fernandez Sampedro M, Guisado Vasco P, Ruano E, Lora Tamayo J, et al. Safety and Efficacy of Prolonged Use of Dalbavancin in Bone and Joint Infections. Antimicrob Agents Chemother. 2019; 63(5). DOI:10.1128/AAC.02280-18.

Ramos Vivas J, Chapartegui Gonzalez I, Fernandez Martinez M, Gonzalez Rico C, Fortun J, Escudero R, et al. Biofilm formation by multidrug resistant Enterobacteriaceae strains isolated from solid organ transplant recipients. Sci Rep. 2019; 9(1): 8928-8928. DOI:10.1038/s41598-019-45060-y.

Manzardo C, Londono MC, Castells L, Testillano M, Luis Montero J, Penafiel J, et al. Direct-acting antivirals are effective and safe in HCV/HIV-coinfected liver transplant recipients who experience recurrence of hepatitis C: A prospective nationwide cohort study (vol 18, pg 2513, 2018). Am J Transplant. 2019; 19(2): 614-614. DOI:10.1111/ajt.15244.

Hirzel C, Ferreira VH, L'Huillier AG, Hoschler K, Limaye AP, Englund JA, et al. Humoral response to natural influenza infection in solid organ transplant recipients. Am J Transplant. 2019; 19(8): 2318-2328. DOI:10.1111/ajt.15296.

Lopez Alad R, Guiu A, Mar Mosquera M, Lopez Medrano F, Cofan F, Linares L, et al. Improvement in detecting cytomegalovirus drug resistance mutations in solid organ transplant recipients with suspected resistance using next generation sequencing. PLoS One. 2019; 14(7). DOI:10.1371/journal.pone.0219701.

Bouza E, Cobo J, Almirante B, Duenas C, Escudero R, Farinas C, et al. Recommendations from a panel of experts on the usefulness of fidaxomicin for the treatment of infections caused by Clostridium difficile. Rev Esp Quimioter. 2019; 32(1): 50-59

Fernandez Ruiz M, Gimenez E, Vinuesa V, Ruiz Merlo T, Parra P, Amat P, et al. Regular monitoring of cytomegalovirus-specific cell-mediated immunity in intermediate-risk kidney transplant recipients: predictive value of the immediate post-transplant assessment. Clin Microbiol Infect. 2019; 25(3). DOI:10.1016/j.cmi.2018.05.010.

Cozar A, Ramos Martinez A, Merino E, Martinez Garcia C, Shaw E, Marrodan T, et al. High delayed mortality after the first episode of Clostridium difficile infection. Anaerobe. 2019; 57: 93-98. DOI:10.1016/j.anaerobe.2019.04.004.

Hidalgo Tenorio C, Vinuesa D, Plata A, Davila PM, Iftimie S, Sequera S, et al. DALBACEN cohort: dalbavancin as consolidation therapy in patients with endocarditis and/or bloodstream infection produced by gram-positive cocci. Ann Clin Microbiol Antimicrob. 2019; 18(1): 30-30. DOI:10.1186/s12941-019-0329-6.

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Trevino A, Soriano V. Infections due to human immunodeficiency virus type 2 and human T-Iymphotropic viruses in Spain. Med Clin. 2014; 142(7): 323-326. DOI:10.1016/j.medcli.2013.06.009.

Rodriguez Pardo D, Pigrau C, Lora Tamayo J, Soriano A, del Toro MD, Cobo J, et al. Gram-negative prosthetic joint infection: outcome of a debridement, antibiotics and implant retention approach. A large multicentre study. Clin Microbiol Infect. 2014; 20(11): 911-919. DOI:10.1111/1469-0691.12649.

Gasch O, Camoez M, Dominguez MA, Padilla B, Pintado V, Almirante B, et al. Emergence of resistance to daptomycin in a cohort of patients with methicillin-resistant Staphylococcus aureus persistent bacteraemia treated with daptomycin. J Antimicrob Chemother. 2014; 69(2): 568-571. DOI:10.1093/jac/dkt396.

von Wichmann MA, Moreno A, Lopez Cortes LF, Ortega E, Mira JA, Quereda C, et al. Efficacy and safety of telaprevir based triple therapy in coinfected patients with advanced fibrosis. Final results of the spanish cohort. Hepatology. 2014; 60(1, SI): 669-670

Rodriguez Alvarez R, Goikoetxea J, Garcia M, Figueras Y, Hernandez L, Montejo M. Endovascular infections by Campylobacter: with regard to two cases. Rev Esp Quimioter. 2014; 27(2): 127-129

Valdivieso A, Martinez Indart L, Prieto M, Gastaca M, Ventoso A, Ruiz P, et al. Risk Factors of Late Arterial Complications in Liver Transplantation. Liver Transplant. 2014; 20(1): 220-220

Valdivieso A, Martinez Indart L, Prieto M, Gastaca M, Ruiz P, Ventoso A, et al. Risk Factors of Early Arterial Complications in Liver Transplantation. Liver Transplant. 2014; 20(1): 293-293

Sun H, Munoz P, Torre Cisneros J, Aguado JM, Lattes R, Montejo M, et al. Tuberculosis in solid-organ transplant recipients: disease characteristics and outcomes in the current era. Prog Transplant. 2014; 24(1): 37-43. DOI:10.7182/pit2014398.

Aguirrebengoa K. Desafíos de lopinavir/ritonavir en la cronicidad de la infección por virus de la inmunodeficiencia humana. Enferm Infecc Microbiol Clin. 2014; 32 Suppl 3: 26-30. DOI:10.1016/S0213-005X(14)70165-X.

Puig Asensio M, Peman J, Zaragoza R, Garnacho Montero J, Martin Mazuelos E, Cuenca Estrella M, et al. Impact of Therapeutic Strategies on the Prognosis of Candidemia in the ICU. Crit Care Med. 2014; 42(6): 1423-1432. DOI:10.1097/CCM.0000000000000221.

Guinea J, Zaragoza O, Escribano P, Martin Mazuelos E, Peman J, Sanchez Reus F, et al. Molecular Identification and Antifungal Susceptibility of Yeast Isolates Causing Fungemia Collected in a Population-Based Study in Spain in 2010 and 2011. Antimicrob Agents Chemother. 2014; 58(3): 1529-1537. DOI:10.1128/AAC.02155-13.

Domingo P, Polo R, Lozano F, López Aldeguer J, Aguirrebengoa K, Estrada V, et al; Panel of Experts of GESIDA and Spanish Secretariat for the National Plan on AIDS. Executive summary of the Consensus Document of GeSIDA and Spanish Secretariat for the National Plan on AIDS on combined antiretroviral treatment in adults infected by the human immunodeficiency virus (January 2013). Enferm Infec Microbiol Clin. 2013;31:604-13. FI: 1,478(Q4)

López-Cortés LE, Del Toro MD, Gálvez-Acebal J, Bereciartua-Bastarrica E, Fariñas MC, Sanz-Franco M, et al; REIPI/SAB group. Impact of an Evidence-Based Bundle Intervention in the Quality-of-Care Management and Outcome of Staphylococcus aureus Bacteremia. Clin Infect Dis. 2013;57:1225-33. FI: 9,374(Q1)

Rodríguez-Sainz A, Escalza-Cortina I, Guio-Carrión L, Matute-Nieves A, Gómez-Beldarrain M, Carbayo-Lozano G, et al. Intracerebral hematoma complicating herpes simplex encephalitis. Clin Neurol Neurosurg. 2013;115:2041-5. FI: 1,234(Q3)

Cisneros JM, Cobo J, San Juan R, Montejo M, Fariñas MC. Education on antibiotic use. Education systems and activities that work. Enferm Infecc Microbiol Clin. 2013;31(Suppl 4):31-7. FI: 1,478(Q4)

Blanco JR, Caro-Murillo AM, Castaño MA, Olalla J, Domingo P, Arazo P, et al. Safety, Efficacy, and Persistence of Emtricitabine/Tenofovir Versus Other Nucleoside Analogues in Naive Subjects Aged 50 Years or Older in Spain: The TRIP Study. HIV Clin Trials 2013;14:204-5. FI: 2,304(Q2)

González de Echavarri Perez de Heredia C, García Perez E, Bereciartua Bastarrica E, Martinez Fernandez G. Absceso de partes blandas, ¿es siempre lo que parece?. Med Clin. 2013. : -0. FI: 1,399(Q2)

Gasch O, Camoez M, Domínguez MA, Padilla B, Pintado V, Almirante B, et al. Predictive factors for early mortality among patients with methicillin-resistant Staphylococcus aureus bacteraemia. J Antimicrob Chemother. 2013;68:1423-30. FI: 5,338(Q1)

Montejo M, Goikoetxea J, Mularoni A, Blanco MJ, Gaafar A, Boado MV, et al; Grupo GAMES. Tropheryma wipplei endocarditis: A report of 3 cases. Rev Esp Quim. 2013;26:168-70. FI: 0,836(Q4)

Sun HY, Munoz P, Torre-Cisneros J, Aguado JM, Lattes R, Montejo M, et al. Mycobacterium Tuberculosis-Associated Immune Reconstitution Syndrome in Solid-Organ Transplant Recipients. Transplantation. 2013;95:1173-81. FI: 3,781(Q1)

Fernández-Hidalgo N, Almirante B, Gavaldà J, Gurgui M, Peña C, de Alarcón A, et al. Ampicillin Plus Ceftriaxone Is as Effective as Ampicillin Plus Gentamicin for Treating Enterococcus faecalis Infective Endocarditis. Clin Infect Dis. 2013;56:1261-8. FI: 9,374(Q1)

Blanco-Vidal MJ, Catalan-Urribarrena G, Lopez JI, del Aguila C, Magnet A, Pomposo-Gaztelu I, et al. Left-sided hemiparesis in a diabetic patient: chronic granulomatous encephalitis due to Acanthamoeba. Rev Neurol. 2013;56:187-8. FI: 1,179(Q4)

López-Soria LM, Bereciartua E, Santamaría M, Soria LM, Hernández-Almaraz JL, Mularoni A, et al. First case report of catheter-related fungemia by Candida nivariensis in the Iberian Peninsula. Rev Iberoam Micol. 2013;30:69-71. FI: 1,312(Q3)

Mensa J, Soriano A, Llinares P, Barberán J, Montejo M, Salavert M, et al. Guía de tratamiento antimicrobiano de la infección por Staphylococcus aureus. Rev Esp Quimioter. 2013;26(Suppl 1):1-84. FI: 0,836(Q4)

Gonzalez-Padilla M, Caston JJ, Vidal E, Arizon JM, Segura C, Montejo M, et al. Epidemiology and clinical impact of infection in patients awaiting heart transplantation. Int J Infect Dis. 2013;17:681-5. FI: 2,357(Q3).

Cantisan S, Lara R, Montejo M, Redel J, Rodriguez-Benot A, Gutierrez-Aroca J, et al. Pretransplant Interferon- Secretion by CMV-Specific CD8+T Cells Informs the Risk of CMV Replication After Transplantation. Am J Transplant. 2013;13:738-45. FI: 6,192(Q1)

Cantisan S, Torre-Cisneros J, Lara R, Zarraga S, Montejo M,  Solana R. Impact of Cytomegalovirus on Early Immunosenescence of CD8+ T Lymphocytes After Solid Organ Transplantation. J Gerontol Ser A-Biol Sci Med Sci. 2013;68:1-5. FI: 4,314(Q1)

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