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Investigación clínica en enfermedades infecciosas

Líneas de investigación

Estudios epidemiológicos, clínicos y de tratamiento antirretroviral en pacientes con infección por VIH.
Epidemiología de VHC en pacientes coinfectados.
Hepatocarcinomas en pacientes coinfectados.
Estudios epidemiológicos de ITS e ITS en pacientes infectados por VIH.
Epidemiología, clínica y tratamiento en las infecciones importadas.
Infecciones osteoarticulares nativas y protésicas.
Estudios epidemiológicos, clínicos de Endocarditis infecciosas e infecciones cardiovasculares.
Estudios epidemiológicos, clínicos y de tratamiento de la infección por SARS-CoV-2.

Actividades del grupo

Entre las actividades del grupo de Investigación Clínica en Enfermedades Infecciosas destaca su trabajo en la infección por VIH, participando en las cohortes VACH ( Grupo español de estudios multicentricos en pacientes con infección por VIH) y CoRis y CoRispe (Cohortes de la Red española de investigación en Sida) y formando parte de la Red de Vigilancia epidemiológica del Centro Nacional de Epidemiología en los grupos EPI-VIH (Epidemiologia de la infección por VIH) y EPI-ITS ( Epidemiologia de las Infecciones de Transmisión Sexual).

Además, forman parte del grupo de estudio GEHEP (Grupo de estudio de Hepatitis virales) con pacientes con coinfección por VIH y Hepatitis, y la cohorte de hepatocarcinomas.

Así mismo trabajan en el grupo de infección Osteoarticular GEIO SEIMC (Grupo de estudio de Infecciones Osteoarticulares de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica) y tienen colaboraciones a nivel estatal, desarrollando parte de su investigación con la Red de Enfermedades Importadas por Viajeros e Inmigrantes (Red REDIVI) (Enfermedades Importadas por viajeros e inmigrantes) y la Red nacional de investigación en endocarditis e infecciones cardiovasculares (GAME) y en estudios multicéntricos nacionales e internacionales en Infección por SARS-CoV-2

Coordinador/a del grupo



Miembros del grupo

  Josefina López De Munain López
 
 
  María Del Mar Cámara Pérez
 
 
  Josu Mirena Baraiaetxaburu Artetxe
 
 
  Óscar Luis Ferrero Benéitez
 
 
  Guillermo García-Alfageme Zarza
 
 
  Iñigo López Azkarreta
 
 
  Mireia De La Peña Trigueros
 
 
  Miriam López Martínez
 
 
  Itxaso Lombide Aguirre
 
 
  Victor Polo San Ricardo
 
 

Publicaciones del grupo

Lopez de Munain J, Camara Perez MM, Lopez Martinez M, Alava Menica JA, Hernandez Ragpa L, Imaz Perez M, et al. Clinical and epidemiological characteristics of Chlamydia trachomatis infection among sexually transmitted infection clinics patients. Enferm Infecc Microbiol Clin (Engl Ed). 2022; 40(7): 359-366. DOI:10.1016/j.eimce.2022.04.001.

Norman FF, Trevino Maruri B, Ruiz Giardin JM, Gullon Pena B, Salvador F, Serre N, et al. Trends in imported malaria during the COVID-19 pandemic, Spain ( plus Redivi Collaborative Network). J Travel Med. 2022; 29(6). DOI:10.1093/jtm/taac083.

Fernandez Vecilla D, Aspichueta Vivanco C, Angulo Lopez I, Baraia Etxaburu Artetxe JM, Renzi F, Diaz de Tuesta Del Arco JL. A case of septic arthritis caused by Capnocytophaga canimorsus in an HIV patient. Access Microbiol. 2022; 4(6): 368-368. DOI:10.1099/acmi.0.000368.

Montejano R, de la Calle Prieto F, Velasco M, Guijarro C, Queiruga Parada J, Jimenez Gonzalez M, et al. Tenofovir Disoproxil Fumarate/Emtricitabine and Baricitinib for Patients at High Risk of Severe Coronavirus Disease 2019: The PANCOVID Randomized Clinical Trial. Clin Infect Dis. 2022. DOI:10.1093/cid/ciac628.

Jurado A, Ugalde G, Ibarrondo NG, Trigueros MDP, Gomez LR. Early biological prosthetic mitral valve endocarditis due to Tropheryma whipplei: experience of an antimicrobial treatment approach. Rev Esp Cardiol. 2022; 75(3). DOI:10.1016/j.rec.2021.09.012.

Cañada JE, Delgado E, Gil H, Sánchez M, Benito S, García Bodas E et al. Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain. Viruses. 2021; 13(1). DOI:10.3390/v13010093.

Delgado E, Fernandez Garcia A, Perez Losada M, Moreno Lorenzo M, Fernandez Miranda I, Benito S et al. Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America. Sci Rep. 2021; 11(1): 11442-11442. DOI:10.1038/s41598-021-90023-x.

Lucas A, Chamorro Tojeiro S, Llenas Garcia J, Salvador F, Zubero Z, Molina I et al. Imported leptospirosis in travellers and migrants in Spain: a study of the +REDIVI collaborative network. J Travel Med. 2021; 28(6). DOI:10.1093/jtm/taab095.

Lopez de Munain J, Camara Perez MM, Lopez Martinez M, Alava Menica JA, Hernandez Ragpa L, Imaz Perez M et al. Clinical and epidemiological characteristics of Chlamydia trachomatis infection among sexually transmitted infection clinics patients. Enferm Infecc Microbiol Clin. 2021. DOI:10.1016/j.eimc.2021.06.004.

Delgado E, Fernandez Garcia A, Perez Losada M, Moreno Lorenzo M, Fernandez Miranda I, Benito S et al. Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America (vol 11, 11442, 2021). Sci Rep. 2021; 11(1). DOI:10.1038/s41598-021-95679-z.

Suarez Garcia I, Alejos B, Ruiz Alguero M, Yubero CG, Moreno C, Bernal E et al. Effectiveness and tolerability of dolutegravir and abacavir/lamivudine administered as two separate pills compared to their equivalent single-tablet regimen in a multicentre cohort in Spain. J Int AIDS Soc. 2021; 24(7). DOI:10.1002/jia2.25758.

Mancheno Losa M, Lora Tamayo J, Fernandez Sampedro M, Rodriguez Pardo D, Munoz Mahamud E, Soldevila L et al. arthroplasty revision: A large multicenter cohort. J Infect. 2021; 83(5): 542-549. DOI:10.1016/j.jinf.2021.09.001.

Otero Guerra L, Gil Alonso L, Lopez de Munain J, Del Romero Guerrero J, Serra Pladevall J, Vazquez F et al. Survey of diagnostic resources for STI in Spain. Enferm Infecc Microbiol Clin (Engl Ed). 2021; 39(8): 390-394. DOI:10.1016/j.eimce.2021.07.002.

Bacque J, Delgado E, Benito S, Moreno Lorenzo M, Montero V, Gil H et al. Identification of CRF66_BF, a New HIV-1 Circulating Recombinant Form of South American Origin. Front Microbiol. 2021; 12. DOI:10.3389/fmicb.2021.774386.

Perez Latorre L, Berenguer J, Mican R, Montero M, Cifuentes C, Puig T et al. HIV/HBV coinfection: temporal trends and patient characteristics, Spain, 2002 to 2018. Euro Surveill. 2021; 26(25). DOI:10.2807/1560-7917.ES.2021.26.25.2000236.

Landiribar JD, Rincony OO, Macias AG. Hyperammonemic encephalopathy in a patient with hereditary hemorrhagic telangiectasia. Med Clin. 2021; 157(8): 402-403. DOI:10.1016/j.medcli.2020.09.0040025.

López de Munain J. The challenge of sexually transmitted infections in the 21st century: Treatment is prevention. Med Clin. 2020; 154(6): 218-220. DOI:10.1016/j.medcli.2019.05.033.

Guerrero Beltran C, Martinez Sanz J, Alvarez M, Olalla J, Garcia Alvarez M, Iribarren JA, et al. The algorithm used for the interpretation of doravirine transmitted drug resistance strongly influences clinical practice and guideline recommendations. J Antimicrob Chemother. 2020; 75(5): 1294-1300. DOI:10.1093/jac/dkaa009.

Suárez García I, Ruiz Algueró M, García Yubero C, Moreno C, Belza MJ, Estébanez M, et al. Physicians' opinions on generic antiretroviral drugs and single-tablet regimen de-simplification for the treatment of HIV infection: a multicentre survey in Spain. J Antimicrob Chemother. 2020; 75(2): 466-472. DOI:10.1093/jac/dkz439.

Macho Aizpurua M, Imaz Perez M, Alava Menica JA, Hernandez Ragpa L, Lopez M, Camara Perez M, et al. Characteristics of genital herpes in Bilbao (Northern Spain): 12-year retrospective study. Enferm Infecc Microbiol Clin. 2020. DOI:10.1016/j.eimc.2020.04.014.

Calderon AJ, Irabien M, Hernandez Aretxabaleta N, Bravo MT, Diaz Roca AB, Ibarra S, et al. Transesophageal endoscopic ultrasound-guided fine needle aspiration for the diagnosis of vertebral infectious spondylodiscitis: a novel approach. Endosc Int Open. 2020; 08(08): 1031-1033. DOI:10.1055/a-1196-1421.

Otero Guerra L, Gil Alonso L, Lopez de Munain J, Del Romero Guerrero J, Serra Pladevall J, Vazquez F, et al. Survey of diagnostic resources for STI in Spain. Enferm Infecc Microbiol Clin. 2020. DOI:10.1016/j.eimc.2020.06.018.

Merchante N, Rodriguez Fernandez M, Figueruela B, Rodriguez Arrondo F, Revollo B, Ibarra S, et al. Impact of HIV on the survival of hepatocellular carcinoma in hepatitis C virus-infected patients. Aids. 2020; 34(10): 1497-1507. DOI:10.1097/QAD.0000000000002578.

Serrano Villar S, Martinez Sanz J, Ron R, Talavera Rodriguez A, Fernandez Felix BM, Herrera S, et al. Effects of first-line antiretroviral therapy on the CD4/CD8 ratio and CD8 cell counts in CoRIS: a prospective multicentre cohort study. Lancet HIV. 2020; 7(8): 565-573. DOI:10.1016/S2352-3018(20)30202-2.

Aguilera Alonso D, Sainz T, Jimenez DE Ory S, Bernardino I, Díez C, Torres B, et al. Clinical, Immunological and Virological Outcomes among youths with perinatal HIV after Transition to Adult Units in Spain from 1997 to 2016. Journal Of Acquired Immune Deficiency Syndromes (1999). 2020. DOI:10.1097/QAI.0000000000002539.

Salvador F, Trevino B, Chamorro Tojeiro S, Pou D, Herrero Martinez JM, Rodriguez Guardado A, et al. Epidemiological and clinical profile of immunosuppressed patients with imported strongyloidiasis: a substudy from a larger cohort of the plus REDIVI Spanish Collaborative Network. Pathog Glob Health. 2020; 115(2): 121-124. DOI:10.1080/20477724.2020.1857491.

Alejos B, Suárez García I, Rava M, Bautista Hernández A, Gutierrez F, Dalmau D, et al. Effectiveness and safety of first-line antiretroviral regimens in clinical practice: a multicentre cohort study. J Antimicrob Chemother. 2020; 75(10): 3004-3014. DOI:10.1093/jac/dkaa246.

Suárez García I, Moreno C, Ruiz Algueró M, Pérez Elías MJ, Navarro M, Díez Martínez M, et al. Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: a multicentre cohort study. Aids Res Ther. 2020; 17(1): 45-45. DOI:10.1186/s12981-020-00302-2.

Ibargoyen Garcia U, Nieto Toboso MC, Montoya Azpeitia E, Imaz Perez M, Hernandez Ragpa L, Alava Menica JA, et al. Epidemiological surveillance study of gonococcal infection in Northern Spain. Enferm Infec Microbiol Clin. 2020; 38(2): 59-64. DOI:10.1016/j.eimc.2019.05.002.

Wikman Jorgensen P, Lopez Velez R, Llenas Garcia J, Trevino B, Pascual R, Molina I, et al. Latent and active tuberculosis infections in migrants and travellers: A retrospective analysis from the Spanish plus REDIVI collaborative network. Travel Med Infect Dis. 2020; 36. DOI:10.1016/j.tmaid.2019.07.016.

Fichtenbaum CJ, Ribaudo HJ, Leon Cruz J, Overton ET, Zanni MV, Malvestutto CD, et al. Patterns of Antiretroviral Therapy Use and Immunologic Profiles at Enrollment in the REPRIEVE Trial. J Infect Dis. 2020; 222: 8-19. DOI:10.1093/infdis/jiaa259.

Herrador Z, Perez Molina JA, Camacho C, Rodriguez Guardado A, Bosch Nicolau P, Calabuig E, et al. Imported cysticercosis in Spain: A retrospective case series from the plus REDIVI Collaborative Network. Travel Med Infect Dis. 2020; 37. DOI:10.1016/j.tmaid.2020.101683.

Rivero Juarez A, Frias M, Lopez P, Berenguer J, Garcia F, Macias J, et al. Hepatitis E 3ra Genotype Infection in People Living With HIV in Spain. Front Microbiol. 2020; 11. DOI:10.3389/fmicb.2020.564486.

Antinori A, Bartmeyer B, Beniowski M, Bonnet F, Brannstrom J, Casabona J, et al. Estimating the burden of HIV late presentation and its attributable morbidity and mortality across Europe 2010-2016. BMC Infect Dis. 2020; 20(1). DOI:10.1186/s12879-020-05261-7.

Beltran Pavez C, Gutierrez Lopez M, Rubio Garrido M, Valades Alcaraz A, Prieto L, Ramos JT, et al. Virological outcome among HIV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997-2017). Sci Rep. 2020; 10(1). DOI:10.1038/s41598-020-70861-x.

Roca B, Spanish Vach Cohort GRP. Factors Associated with Nonsuppression of HIV Infection in the Spanish VACH Cohort. AIDS Res Hum Retroviruses. 2020; 36(11): 927-932. DOI:10.1089/aid.2020.0016.

Vourli G, Noori T, Pharris A, Porter K, Axelsson M, Begovac J, et al. Human Immunodeficiency Virus Continuum of Care in 11 European Union Countries at the End of 2016 Overall and by Key Population: Have We Made Progress?. Clin Infect Dis. 2020; 71(11): 2905-2916. DOI:10.1093/cid/ciaa696.

López de Munain J. Epidemiology and current control of sexually transmitted infections. The role of STI clinics. Enferm Infecc Microbiol Clin. 2019; 37(1): 45-49. DOI:10.1016/j.eimc.2018.10.015.

Hernández Ragpa L, Valladolid Urdangaray A, Ferrero Benéitez OL, Díez Sáez C. Sexually transmitted infections in the context of a sexual assault. Enferm Infecc Microbiol Clin. 2019; 37(3): 187-194. DOI:10.1016/j.eimc.2018.11.004.

Delgado E, Benito S, Montero V, Cuevas MT, Fernandez Garcia A, Sanchez Martinez M, et al. Diverse Large HIV-1 Non-subtype B Clusters Are Spreading Among Men Who Have Sex With Men in Spain. Front Microbiol. 2019; 10: 655-655. DOI:10.3389/fmicb.2019.00655.

Teira R, Espinosa N, Gutiérrez MM, Montero M, Martínez E, González F, et al. Losses to follow-up of HIV-infected people in the Spanish VACH cohort over the period between 2013 and 2014: The importance of sociodemographic factors. Enferm Infecc Microbiol Clin. 2019; 37(6): 361-366. DOI:10.1016/j.eimc.2018.09.008.

Henriquez Camacho C, Serre M, Norman F, Sanchez Montalva A, Torrus D, Josune Goikoetxea A, et al. Clinicoepidemiological characteristics of viral hepatitis in migrants and travellers of the plus Redivi network. Travel Med Infect Dis. 2019; 29: 51-57. DOI:10.1016/j.tmaid.2019.02.001.

Benito N, Mur I, Ribera A, Soriano A, Rodriguez Pardo D, Sorli L, et al. The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms. J Clin Med. 2019; 8(5). DOI:10.3390/jcm8050673.

Salvador F, Trevino B, Chamorro Tojeiro S, Sanchez Montalva A, Maria Herrero Martinez J, Rodriguez Guardado A, et al. Imported strongyloidiasis: Data from 1245 cases registered in the plus REDIVI Spanish Collaborative Network (2009-2017). Plos Neglect Trop Dis. 2019; 13(5). DOI:10.1371/journal.pntd.0007399.

Alejos B, Suárez García I, Bisbal O, Iribarren JA, Asensi V, Górgolas M, et al. Choice of the initial antiretroviral treatment for HIV-positive individuals in the era of integrase inhibitors. PLoS One. 2019; 14(8). DOI:10.1371/journal.pone.0221598.

Teira R, Diaz Cuervo H, Aragao F, Castano M, Romero A, Roca B, et al. Shorter time to treatment failure in PLHIV switched to dolutegravir plus either rilpivirine or lamivudine compared to integrase inhibitor-based triple therapy in a large Spanish cohort - VACH. HIV Med. 2019; 20: 25-26

Bernal E, Munoz A, Alcaraz A, Alcaraz MJ, Valero S, Viciana P, et al. Prediction of virological failure in patients with low level HIV-1 viremia using a joint latent class model. HIV Med. 2019; 20: 67-67

Teira R, Gutierrez M, Galindo P, Martínez E, Muñoz P, de la Fuente B, et al. Integrase strand-transfer inhibitors for treatment of early HIV infection: A case series. Medicine (Baltimore). 2019; 98(35). DOI:10.1097/MD.0000000000016866.

Salvador F, Trevino B, Herrero Martinez JM, Rodriguez Guardado A, Torrus D, Goikoetxea J, et al. EPIDEMIOLOGICAL AND CLINICAL PROFILE OF IMMUNOSUPPRESSED PATIENTS WITH IMPORTED STRONGYLOIDIASIS: A SUBSTUDY FROM A LARGER COHORT OF THE plus REDIVI SPANISH COLLABORATIVE NETWORK. Trans Roy Soc Trop Med Hyg. 2019; 113: 46-47

Merchante N, Figueruela B, Rodríguez Fernández M, Rodríguez Arrondo F, Revollo B, Ibarra S, et al. Low performance of ultrasound surveillance for the diagnosis of hepatocellular carcinoma in HIV-infected patients. Aids. 2019; 33(2): 269-278. DOI:10.1097/QAD.0000000000002065.

Pérez Arellano JL, Górgolas Mora M, Salvador F, Carranza Rodríguez C, Ramírez Olivencia G, Martín Echeverría E, et al. Executive summary of imported infectious diseases after returning from foreign travel: Consensus document of the Spanish Society for Infectious Diseases and Clinical Microbiology (SEIMC). Enferm Infecc Microbiol Clin. 2018; 36(3): 187-193. DOI:10.1016/j.eimc.2017.02.009.

Rodríguez Arrondo F, von Wichmann MÁ, Camino X, Goenaga MÁ, Ibarguren M, Azcune H, et al. A case-control study of non-AIDS-defining cancers in a prospective cohort of HIV-infected patients. Med Clin. 2018; 150(8): 291-296. DOI:10.1016/j.medcli.2017.03.032.

Berenguer J, Jarrín I, Pérez Latorre L, Hontañón V, Vivancos MJ, Navarro J, et al. Human immunodeficiency virus/hepatits C virus coinfection in Spain: Elimination is feasible, but the burden of residual cirrhosis will be significant. Open Forum Infect Dis. 2018; 5(1). DOI:10.1093/ofid/ofx258.

Bernal E, Gómez JM, Jarrín I, Cano A, Muñoz A, Alcaraz A, et al. Low-Level Viremia Is Associated With Clinical Progression in HIV-Infected Patients Receiving Antiretroviral Treatment. JAIDS. 2018; 78(3): 329-337. DOI:10.1097/QAI.0000000000001678.

Merchante N, Rodríguez Arrondo F, Revollo B, Merino E, Ibarra S, Galindo MJ, et al. Hepatocellular carcinoma after sustained virological response with interferon-free regimens in HIV/hepatitis C virus-coinfected patients. Aids. 2018; 32(11): 1423-1430. DOI:10.1097/QAD.0000000000001809.

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