Inflamación y biomarcadores

Líneas de investigación

Genética y biomarcadores en la EM. Estamos desarrollando un enfoque combinado de OMICS para identificar biomarcadores y mecanismos de subtipos de células dendríticas en esclerosis múltiple primaria progresiva y remitente recurrente.
Identificación de variantes de riesgo de gravedad de COVID-19 mediante un array basado en un microarray extenso de SNPs.
Biomarcadores de vulnerabilidad de aterosclerosis carotídea y accidente cerebrovascular.

Coordinador/a del grupo

Koen Vandenbroeck
Coordinador de grupo
k.vandenbroeck@ikerbasque.org
844748
CV resumen

Miembros del grupo

Iraide Alloza Moral

| 844749

Ana María Lozano Ladero

Raquel Tulloch Navarro

Ane Aldekoa Etxabe

| 844681

César Martín Plagaro

César Augusto Martín Plagaro

Ainhoa Fiat Arriola

| 844681

Jebari Benslaiman S, Uribe KB, Benito Vicente A, Galicia Garcia U, Larrea Sebal A, Santin I, et al. Boosting Cholesterol Efflux from Foam Cells by Sequential Administration of rHDL to Deliver MicroRNA and to Remove Cholesterol in a Triple-Cell 2D Atherosclerosis Model. Small. 2022; 18(13). DOI:10.1002/smll.202105915.

Alcina A, Fedetz M, Vidal Cobo I, Andres Leon E, Garcia Sanchez M, Barroso Jesus A, et al. Identification of the genetic mechanism that associates L3MBTL3 to multiple sclerosis. Hum Mol Genet. 2022; 31(13): 2155-2163. DOI:10.1093/hmg/ddac009.

Jebari Benslaiman S, Galicia Garcia U, Larrea Sebal A, Olaetxea JR, Alloza I, Vandenbroeck K, et al. Pathophysiology of Atherosclerosis. Int J Mol Sci. 2022; 23(6). DOI:10.3390/ijms23063346.

Benslaiman SJ, Uribe KB, Benito Vicente A, Galicia Garcia U, Larrea A, Alloza I, et al. BOOSTING CHOLESTEROL EFFLUX FROM FOAM CELLS BY SEQUENTIAL ADMINISTRATION OF RHDL TO DELIVER MICRORNA AND TO REMOVE CHOLESTEROL IN A TRIPLE-CELL TWO-DIMENSIONAL ATHEROSCLEROSIS MODEL. Atherosclerosis. 2022; 355: 19-19

Bennett M, Ulitsky I, Alloza I, Vandenbroeck K, Miscianinov V, Mahmoud AD et al. Novel Transcript Discovery Expands the Repertoire of Pathologically-Associated, Long Non-Coding RNAs in Vascular Smooth Muscle Cells. Int J Mol Sci. 2021; 22(3). DOI:10.3390/ijms22031484.

Mena J, Alloza I, Tulloch Navarro R, Aldekoa A, Díez García J, Villanueva Etxebarria A et al. Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55-IL6ST Gene Region in Immature Dendritic Cells. Front Immunol. 2021; 12: 816930-816930. DOI:10.3389/fimmu.2021.816930.

Jebari Benslaiman S, Uribe KB, Benito Vicente A, Galicia Garcia U, Larrea Sebal A, Alloza I, et al. Cholesterol Efflux Efficiency of Reconstituted HDL Is Affected by Nanoparticle Lipid Composition. Biomedicines. 2020; 8(10). DOI:10.3390/biomedicines8100373.

Alloza I, Salegi A, Mena J, Navarro RT, Martin C, Aspichueta P, et al. BIRC6 Is Associated with Vulnerability of Carotid Atherosclerotic Plaque. Int J Mol Sci. 2020; 21(24). DOI:10.3390/ijms21249387.

Tesis del grupo

2021
2019
2018

Autor/a: Paloma Gómez Fernández . Título: "Characterization of the Isoforms of the Multiple Sclerosis Risk Protein, IL-22 Binding Protein (IL-22BP)". Directores/as: Dra. Iraide Alloz Moral, Dr. Koen Vandenbroeck.

Autor/a: Nerea Ugidos Damboriena. Título: Functional analysis of ANKRD55, a multiple sclerosis risk gene with unknown function. Directores: Dr. Koen Vandenbroeck.

Autor/a: Haize Goikuria Iriondo. Título: Characterization of smooth muscle cells isolated from symptomatic and asymptomatic carotid atheroma plaques. Directores: Dra. Iraide Alloza Moral, Dr. Koen Vandenbroeck.